Tricyclics. CNS depressants, alpha-blockers, beta-blockers, calcium channel blockers

Other antihyperetensives

Digitalis

Hypertension

Drowiness, dry mouth Weight gain, odema,weakness,

Rash, constipation ,urticaria, myalgia

Nausea, insomnia, agitation, Impotence, orthostatic hypotension, arrhythmias,

Dryness of eyes (caution for contact lens users) Dellusional perception, paraesthesia

Salivary gland pain, Visual accomodation disorder

Sports events - restricted

Known hypersensitivity to chlorthalidone

Severe renal or hepatic disease, (coma hepaticum)

Sick sinus sydrome.

Severe coronary insufficiency.

Conduction disturbances

Recent MI   Renal failure    Cerebrovascular disease

Pregnancy - Discontinue 4 hours surgery, resume as soon as possible after surgery Initiation and termination of therapy should be performed gradually to avoid suddden excessive decrease or increase repy in blood pressure

Do not discontinue therapy abruptly without adequate substitution therapy

Lactation

Depression. peripheral vascular disease.

Porphyria

Indication-

Hypertension

Dosage-

1/2 tablet at bed time initially May be increased to 450mcg daily

Contraindicated for use during pregnancy and lactation.

Observe caution