Fluorouracil- Anti-cancer drug
Drug Name:
Fluorouracil- Anti-cancer drug
List Of Brands:
Indication Type Description:
Drug Interaction:
May increase warfarin effects.
May reduce response to vaccines possibility of generalized infection with live vaccines
Action may be modified by Allopurinol
Leucovorin Ca may enhance toxicity of fluorouracil
Indication:
Palliatice treatment of breast carcinoma, of the colon, rectum
breast, stomach or pancreas
Adverse Reaction:
Leucopenia, thrombocytopaenia, stomatitis, GI ulceration, bleeand ding and diarrhoea haemorrhage, from any site(stop treatment)
Nausea, vomiting, rashes, hyperpigmentation, alopecia,
Topical- Local Inflammatory and photosensitivity reactions,
Dermatitis and erythema multiforme( rare)
Central neurotoxicity, myocardial ischaemia
Contra-Indications:
Contraindications-
Topical application to mucous membrane, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutrional status, potentialy serious infections
Pregnancy and lactation
Special Instructions-
Regular monitoring f bloos counts, History of heart disease , hepatic or renal insufficiency,weak or malnourished patients, patients who with history of high dose pelvic radiation or use of alkylating agents. Patients with widespread metastases to the bone marrow
Dosages/ Overdosage Etc:
Indication-
Palliatice treatment of breast carcinoma, of the colon, rectum
breast, stomach or pancreas
Dosage-
Oral- 15mg/kg (max 1g dailly) may be given once weekly for maintenance
Maximum dose - 1g/week
Intravenous- Adult- 5-7.5mg/kg daily continous infusion (regional perfusion)
