Potentiates hypoglycemic agents

Bismuth catbonate & Mg reduce absorption

Cimetidine , allopurinol , diuretics, and other oral antocoagulants enhance effect. Vit K reverses effect.

Potentiated by NSAIDs , amiodarone, antibacterial agents eg. co-trimoxazole, cephalosporin, eryhthromycn, quinolone antibiotics, chloramphenicol, doxycycline, INH and neomycin

Rifsampicin ,barbiturates and griseofluvin reverses effect.

Thromboembolic disorders

Alopecia,fever, nausea, vomting, diarrhoea, skin rash, cholestatic jaundice, Liver damage, Haemorrhage

Active hemorhage or risk of serious hemorrhage

Severe hypertension

Special precaution

Bleeding disorders, peptic ulcers, severe wounds,

Cerebral vascular disorders

Bacterial endocarditis

Renal or hepatic impairment

Lactation Avoid alcohol

Indication

Thromboembolic disorders

Dosage

Adult- 4-12 mg on the ist day and 4-8mg on the second day

Maintenance - 1 -8mg daily given as a single dose at the same time every day

Special Precaution-

Patient with severe heart failure, knon or suspected protein C or Vitamin K defeciency. Mild to moderate hepatic & renal impairment

Use caution when administering to pregnant and lactating mothers