As per US FDA guidelines as per USPDA 1997

It is the intention to bring out the salient features. Hence relevent details as prescribed by US FDA guidelines as per USPDA 1997  are brought out clearly in the following chapters. 

Descriptons are detailed only to the Group Head and the indiviual items can be seen by visiting the Web Site 

ANTIDEPRESSANTS-

TRICYCLIC ANTIDEPRESSANTS -(TCAD)

Includes- Amitriptyline, Clomipramione, Doxepin, Imipramine, Nortriptyline,Tripramine, Dothiepin

Tricylic Compounds include-

      Tertiary amines - Amitriptyline,Clomipramine,Doxepin,Imipramine,Trimipramine
      Secondary amines - Amoxapine, Desipiramine, Nortriptyline,Portriptyline
      Refer - Amitriptyline

 Tetracyclines Compounds include -  Maprotiline, Mitrazapine, Mianserin
        
Triazolopyridine  group  - Trazadone
    
 Aminoketone  group -- Bupropion
        
Phenypiperazine group - Nefazodone  
   
Phenethylamine  group  - Venlafaxine

SELECTIVE SEROTININ REUPTAKE INHIBITORS-(SSRI)

Includes- Fluoxetine, Fluvoxamine, Paroxetine, Cotalopram, Escitalopram, Reboxetine and Sertraline

Tricylic Compounds-

 Refer - Amitriptyline

1. Do not discontinue therapy or take other drugs without the consent of physician. Abrupt discontinuation of therapy may cause nausea,headache and malaise.

2. May cause drowsiness or blurred vision. Use caution while driving or performing other tasks which require alertness.

3. Avoid taking alcohol or other CNS depressant drugs

4. Avoid prolonged exposure to sunlight or sunlamps; photosensitivity may occur.

5. Allergies

Tell your doctor if you have ever had any unusual allergic reaction to any tricyclic antidepressant to carbamazepine, maprotiline or trazadone. Also tell to your if you are allergic to any substances such as foods, preservatives or dyes.

6. Pregnancy

Studies in animals have shown that some tricyclic antidepressants may cause unwanted effects in the fetus.

7. Breast feeding

Tricyclic antidepresants pass into breast milk. Doxepin have been reported to cause drowsiness in the nursing babies.

8. Children

Children are specially sensitive to the effects of this medicine. Side effects in children taking this medicine for bedwetting usually disappears on continued use. Other most common side effects are nervousness, sleeping problems, tiredness, and mild stomach upset. Check with your doctor if these side effects continue to persist.

9. Elderly

Drowsiness, dizziness, confusion, vision problems, dryness of mouth, constipation, and problems in urinating are more likely to occur in elderely patients.

10. Other medicines

If you taking tricyclic antidepressants, it is necesary for your doctor to know if you are taking any other medicines- Amphetamine or Appetite suppressants or Ephedrine or ephinephrine or Isoproterenol or Medicine for asthma or for colds , sinus problems, or hay fever or other allergies or Phenylephrine- use of these medicines with tricyclic may increase the risk of serious side effects on the heart

11. Other medical problems

Tell your doctor ifyou have any other medical problems- Alcohol abuse- drinking alcohol may cause increased CNS depresant efects. Asthma or Biploar disorder or Blood disorders or Convulsions or Difficult urination or Enlarged prostrate or Glaucoma or increased eye pressure or Heart disease or High blood pressure ir Schiophrenia - tricyclic antidepressants may make the conditiond worse

 12. Missed dose

if you miss a dose and dosing is Once a day at bed time- do not take mised dose in the morning since it may cause disturbing side effects during waking hours. check with your doctor More than one dose a day- take the mised dose as soon as possible. However if it is almost time for the next dose , skip the missedcdose and go back to your regular schedule. Do not double doses.

13. Storage

Keep out of reach of children. Overdose of this medicine is too dangerous for children. Store away from heat and direct light. Do not store the tablet or capsule form of this medicine in the bathroom,near the kitchen sink or in other damp places Keep the liquid formof this medicine from freezing Do not keep outdated medicines. Be sure that discarded medicine is out of reach of children

14. Food

Take with or without food

15. AVOID CONCURRENT USE WITH ERYTHROMYCIN

SELECTIVE SEROTININ REUPTAKE INHIBITORS-(SSRI)

Includes- Fluoxetine, Fluvoxamine, Paroxetine, Cotalopram, Escitalopram, Reboxetine and Sertraline

Refer- Fluoxetine

1. May cause dizziness. Observe caution while driving or performing tasks requiring alertness, coordination or physical dexterity.

2.Avoid alcohol or other CNS depressants medicines.

3. Concomitant medication- Consult physician or pharmacist before taking concomittant OTC products or prescription drugs

4. Pregnancy or lactation- Notify physician of pregnancy, ofintent to become pregnant or if breast feeding

5. Rash- Notify physician if rash hives develop.

6.Completing course of therapy- While patients may notice improvement in therapy in 1 to 4 weeks, advise patients to continue therapy as directed.

7. Allergies- Tell your doctor if you have ever had any unusual or allergic reactions to fluoxetine or related medicines. Also tell your doctor if your are allergic to any other substances such as foods, preservatives or dyes.

8. Pregnancy- fluoxetine has not been shown to cause birth defects or other problems in animal studies

9.Breast feeding- be sure you have discussed the risk and benefits of this medicine with your doctor.

9.Children- not expected to cause different side effects or problems in children

10. Elderly- not shown to cause different problems in elderly people than in younger adults.

11. Other Medicines -Tell your doctor if you are taking any of the following- Anticoagulants or Digitalis glycosides- higher or lower blood levels of the these medicines or fluoxetine may occur- your doctor may need to change your dose CNS depressants-

11. Other medical problems- presence of other medical problems may affect the use of this medicine- Diabetes - the amount of insulin or oral antidiabettic medicine that you need mat change Kidney disease or Liver disease - higher blood levels of fluoxetine may occurincreasing the chance of side effects. Seizures- the risk of seizures may be increased

12. Missed dose- If you miss a dose of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double dose