NASAIDs , oral hypoglycemics, sulphonamides, Quinidine, cimetidine, Antibiotics, corticosteroids, Drugs affecting liver enzymes. Vitamin K

Thrombo-embolism

Bleeding, allergy, liver damage, reversible alopecia, skin necrosis, headache, anorexia

Haemorrhagic conditions Impaired renal or hepatic function within 24 hours of surgery or labour Blood dyscrasis, pericarditis, Pericardial effusion, subacute bacterial endocarditis Pregnancy

Special precautions:

Lactation Hypertension, elderly, reduced protein binding GI disorders, severe hepatic failure, hepatic dysfunction

Dosage-

8-12 mg on ist day 4 - 8mg on 2nd day Maintenance dose- usually 1-8 mg daily

Not reported.

Contraindicated for use during pregnancy and lactation- Use only if needed