Coumarin anticoagulants and hypoglycemics agents ( especially sulphonylureas)

Certain anti-inflammatory agents, Uricosuric agents, methotrexate, diuretics, and corticosteroids.

Antacids with enteric coated prepn.

Valproic acids, Acetotazolamide,  Highly protein bound drugs

Urinary alkalinizers, Ace inhibitors, betablockers.

Chronic heavy alcohol use

Cimetidine, Contraceptives oral,

Disulfram ,Fluroquimolones,Cipropfloxacin,Enoxacin,

Caffeine metabolism impaired

Phenylpropanolamine - serum caffeine level increased

Smoking- elimination of caffeine enhanced

Mexilitine - caffeine clearance decreased

Juvenille rheumatoid arthritis

Allergic or asthmatic reactions

GI upset/bleed

Prolonged bleeding time.

Anaphylaxis, salicylism

Reyes syndrome

Sports events- restricted

Peptic ulcer Haemophillia or other bleeding disorders.

Aspirin/anti-inflammatory induced allergies

Viral infection in children and teen agers

Lactation

Special precautions-

Gout

History of bronchospasam or asthma

Impaired renal or hepatic function.

Dyspepsia, diabetes

Elderly

Children

Pregnancy (avoid at term)

Indication

Juvenille rheumatoid arthritis

Dosage-

Aspirin Child- 80-100mg/kg daily in 5 or 6 divided dose Upto 130mg/kg/ daily in acute excerbations if necessary

Pain/inflamtion- adult- initial 2.4- to3.6 g/day in divided doses.

Maintenance - 3.6 to 5.4 g /day .

Monitor serum concentrates

Mild to moderate pain  Adult- initial - 325-650mg repeated every 4- 6 hr acccording to response. Max 4g/day also be given Aspirin +Caffeine 2 tabs thrice after food

To be taken after food

Contraindicated for use during pregnancy and lactaion

Observe caution if use is needed.