Benzodiapines include- Alprozolam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam Halazepam, Lorazepam, Oxazepam, Prazazepam Refer Diazepam 

Interacting drugs - summary

+ Nitrazepam

Alcohol-                                                                                                                           additive CNS depressant effects. Potential for interaction continues for several days CNS depressants following flurazepam withdrawal 

CNS depressant effect increased by alcohol,barbiturates,tricylic antidepressants, phenothiazines, morphine derivatives.

Enhances effect of amitriptyline.antagonised by methyl phenidate.

Antacids delay absorption.

Interacting drugs - summary

+ Nitrazepam Alcohol ) incr additive CNS depressant efects CNS depressants ) 

Benzodiapines include- Alprozolam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam Halazepam, Lorazepam, Oxazepam, Prazazepam Refer Diazepam

Anaphylaxis. Drowsiness,light headedness,hangover effect(elderly). Rebound insomnia on withdrawal

.May also experience anxiety,tension,photophobia.

Myastenia gravis.Benzodiapene hypersens.

Special precautions:

May cause drowsiness,ataxia,congitive deficits in elderly, gradual withdrawal.

Indications: Sedative hypnotic.

Dosage: 2.5 to 10mg/day in divided doses.

Benzodiapines include-

Alprozolam, Chlordiazepoxide, Clonazepam, Clorazepate,Diazepam Halazepam, Lorazepam, Oxazepam, Prazazepam Refer Diazepam 

1.May cause drowsiness,avoid driving or tasks requiring alertness.

2.Avoid alcohol or CNS depressants.

3.May be taken with food or water if stomach upset occurs.

4. Patient on long term or high dosage therapy may experience withdrawal symptoms on abrupt cessation of therapy; do not discontinue therapy abruptly or change dosage except on advice of physician.

5. Concomittant ingestion with antacids may alter the rate of absorption of these drugs.

Pharmacology:

Benzodiapines appear to potentiate the effects of gamma-aminobutyrate(GABA). The activity of benzodiapines involve the following sites: spinal cord(muscle relaxation),brain stem, cerbellum, limbic and cortical areas.

Phamacokinetics:

Benzodiapines are readily absorbed following oral administration.

Not available

Pregnancy:

Avoid use during pregnancy. Advise patients that if they become pregnant or plan to become pregnant, they should discuss the desirability of discontinuing the drug,with the doctor.

Lactation:

Benzodiapines are excreted in breast milk. Since neonates metabolise benzodiapines more slowly,accumulation of the drug and the metabolites to toxic levels is possible.

Children:

Initial dose should be small and dosage increment should be gradual,according to the response of the patient.