CNS depressants- propiomazine enhances the CNS effects. Eliminate or reduce the dose of barbiturate by at least in the presence of propiomazine. Reduce the dose of mepiridine, morphine and other analgesic depressants by 1/4 to 1/2.

Sedative.

Dry mouth may occur. Moderate elevation of blood pressure. Hypotension (rare). Tachycardia

Intra-arterial injection- arterial/arteriolar spasm with local circulation impairment may occur. Special precautions: Neuroleptic malignant syndrome (NMS) a potentially fatal symptom complex has occured in association with antipsychotic drugs. Thrombophlebitis- do not allow extravasation, since chemical irritation may be severe. Hazardous tasks- observe caution

Indications:

Sedative, analgesic adjunct

Dosage:

Adults- administer IM or IV 20mg propiomazine with 50mg meperidine. Some may require 40mg for adequate sedation

Pharmacology: The phenothiazine compound with sedative, antiemetic and antihistaminic properties is a potent premedicant, with a short duration of action.

Pharmacokinetics: Following IM administration,peak serum concentrations are reached in 1 to 3 hours, mean bioavailability is 60%.

Not known

Pregnancy: Safety for use during the first trimester has not been established