Indication- Parkinson's disease either used alone or as adjunct to co-beneldopa , moferate to severe restless syndrome

Side effects-

nausea, vomitting, dyspepsia, abdominal pain dyspepsia, dyspnoea, rhinitis, hallucinnations, dyskiniea, drowsiness, including sudden onset of sleep),diplopea, also reorted constipation, diarrheoa, hiccups, tachycardia, atrial premature contractions, palpitations, hypotension, syncope, Raymunds phenomena, compulsive behavoiur, ,insonia, confusion, dizziness, fever, erythrmelagia and rash

Cautions- opthalmic testing recommended, avoid exposure of patch to heat, withdraw gradually

Hepatic information- caution in severe impairment, - no information available

Breast feeding- may suppress laction, avoid - present in milk in animal studies

Dose- monotherapy- in Parkinson's disease, , initially apply 2mg/24 hours patch, increased in steps of 2mg/24 hours at weekly intervals, if required.

 Max 8mg/24 hours

Adjunctive therapy with levodopa in Parkinson disease, initially apply 4mg/24 hours n steps of 2mg /24 hours at weekly intervals if required, max 16mg/24 hours

Resless leg syndrome, initially apply 1mg/24 hours patch increased in steps of 1mg/24 hours at weekly intervals if requied. Max 1mg/24 hours

Brand- Pergolide (non- properiety)

Note- Apply patch to dry non-irrited skin on torso, thigh, or upper arms removing after 24 hiurs and siting replacement patch on a different ares( avoid using the same area for 14 days)