As per US FDA guidelines as per USPDA 1997

It is the intention to bring out the salient features. Hence relevent details as prescribed by US FDA guidelines as per USPDA 1997  are brought out clearly in the following chapters. 

Descriptons are detailed only to the Group Head and the indiviual items can be seen by visiting the Web Site

ANTIDYSKINETIC-

Amatadine(systemic)                                                                                          Benztropine (systemic)                                                                                          Bipriden (systemic)                                                                                                            Bromocriptine (systemic)                                                                                                Carbidopa and Levodopa (systemic)                                                                              Diphenylamine (systemic)                                                                                                Ethopropazine (systemic)                                                                                                  Levodopa (systemic)                                                                                                          Levodopa and Benserazide (systemic)                                                                            Procyclidine (systemic)                                                                                                    Selegiline (systemic)                                                                                                          Trihexyphenidyl (systemic)

Antidyskinetic , dopamine agent-                                                                                    Pergolide (systemic)

Antidyskinetic, Gilles de la Tourett's syndrome-                                                            Haloperodol (systemmic)                                                                                                  Pimozide (systemic)

Antidyskinetic, Huntinton's chorea -                                                                                Chlorpromazine (systemic)                                                                                              Haloperidol (systemic)                                                                                                      Thioridazine (systemic)

Levodopa

1.May cause GI upset; take with food.

2.Avoid vitamin products containing B-6(pyridoxine hcl).

3.Observe caution while driving or performing tasks requring alertness.

4.If fainting, lightheadedness or dizziness occurs,avoid suddenchanges in posture. Inform your doctor.

5.Medication may cause darkening of urine or sweat. This efect is not harmful.

6.Allergies- tell your doctor if you have ever had any unusual or allergic reaction to levodopa alone or in combination with carbidopa. Also tell your doctor if you are allergic to any other substances, such as foods, presrvatives or dyes.

7. Diet- for patients taking levodopa by itself- Pyridoxime - (Vitamin B6)- has been found to reduce the effects of levodopa when levodopa is taken by itself. If you are taking levodopa by itself, do not take vitamin products containing vitamin B6 during treatment, unless prescribed by your doctor

8.Pregnancy - studies not done in pregnant women. However, studies in rabbits have shown that levodopa alone or in combination with caridopa causes birth defects.

9.Breast feeding- levodopa pass into breast miolk and may cause unwanted side effects in the nursing baby.

10. Children - no specific information comparing use of levodopa in children with use in other age groups

11. Elderly- elderly people are more sensitive the efects of levodopa and increase the chance of side effects.

12. Other medicines - Let your doctor know what other medicines you are taking, so that he can advice you accordingly. Cocaine- cocaine used by individuals taking levodopa alone or in combination with carbidopa may cause irregular heartbeat Ethotoin or Haloperidol or Mephenytoin or Phenothiazines or Phenytoin - taking these medicines together with levodopa may lessen the effect of levodopa MAOI- taking levodopa while you are taking or within 2 weeks of taking MAOI may cause sudden extremely high blood pressure. At least 14 days should be allowed between stopping treatment with one medicine and starting treatment with the other medicine Pyridoxine Vitamin B6- pyridoxine reverses the effect of levodopa Selegiline- dosage of levodopa and levidopa combination may need to decreased

13. Other medical problems - Tell your doctor if you have any other medical problems especially - Diabetes mellitus- the amount of insulin that you need may change Emphysema-, asthma, bronchitis or Glaucoma or Heart or blood vessel disease or Hormone problems or Melanoma - a type of cancer or Mental illness -levodopa may make the conditions worse Kidney diseasse or Liver disease - higher blood levels of levodopa may occur which may increase the chance of side effects Seizure disorders - risk of seizures may be increased Stomach ulcer - ulcer may occur again

14. Missed dose - If you miss a dose of this medicine, take it as soon as possible. however, if it is almost time for the next dose, skip the missed dose. Do not double doses.

15. Storage - Keep out of reach of children. Store away from heat or direct sunlight. Do not store the capsule in bathroom, near the kitchen sink, or in other damp places.

16. Outdated medicines - Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of reach of children.