Immunosupressants- Patients receiving other immunosuppressants should not receive concurrent therapy with Alfacept because of the possibility of ecxessive immunosuppression
ALFACEPT - Immunosuppressiives
Product - AMEVIVE BIOIGEN IDEEC
Powder for Injection lyophilized 12.5mg sucrose presrvative free in dose pack 1s and 4s
Plaque posoriasis- treatment of adult apatients with moderatte to severe chronic plaque psoriasis who are andidates for systemic therapy or phototherapy
The recommende dosage of alfacept is 15mg given onceweekly intramuscular (IM injectioin. Therecommended regimen is is acourse of 12 weekly injection.
Retreatment with additonal 12 week course may be initiated provide that CD4 + T lymphocytes countsare within normal range and a minimum of a 12 week interval has been passed since the previous course of treatment
Do not administer to patients infected with HIV. Alfacept reduces CD4 +T lymphocytes count which might accelrate disease progression otr increase complications of the disease to the patients
Inform patients fo regular monitoring of whiteblod cell count( lymphcytes) ciunts during therapy and that Alfacept must be administerd under thesupervision of health care provider.
Also advice female patients to notify their health care provider if they become pregnant whle taking Alefacept
Advice patients that serioys liver injury has been reported in patienbts receiving Alfacept. Advice patients to teport to the halth care provider persistent nausea, anorexia, farigue, vomitting, abdominal pain, jaundice, easy brusing, dark urine or pale stools.
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