Cimetidine decreases serum conc. of chlordiazepoxide

Absorption impaired by mag, silicate, morphine, pethidine, atropine

Absorpitin enhanced by metoclopromide and alum, hydroxide

Potentiates action of major neuroleptics

Chlordiazepoxide- Alcohol potentiates chlordiazepoxide and concurrent use of both could be dangerous

Amitriptyline- Potentiates sedative action of alcohol

Antiparkinsonian agents and antipsychotic drugs increase risk of anticholinergic effects.

Reduced effects of antihypertnsives Marked hypeplexia, convulsions and coma with MAOI

Potentiates hypertensive effects of sympathomimetics

Anxiety

Physical and psychological dependence

Withdrawal syndrome Impairs psychomotor performance

More accidental prone

Aggression in predisposed individuals esp. in combination with alcohol

Postural hypotension, tachycardia, conduction disturbances

Dry mouth , weight gain, sour or metallic taste

Stomatitis, constipation,

Blurring of vision,

Urinary retention

Fatigue, weakness, dizziness

Tremors, headache, confusion and delirium in elderly

Weight gain, tardive dyskinesia

Neuloeptic malingnant syndrome, sexual disturbances

Agranulocytosis, thrombocytopenia

Cardiac arrhythmias

Hypersensitivity to benzodiazepines or MAO inhibitors

Jaundice, myastenia gravis, acute pulmonary insufficiency and respiratory depression

Depression, prophyria, heart block, cardiac arrhythmias, severe hepatic disease

Pregnancy, lactation

Special Precaution-

Alcohol, sedation, dependence

Elderly and debilitated patients Liver or kidney dysfunction

Bipolar illness Recovery after MI ,

CVS diseases, epilepsy,

Psychoses, abrupt withdrawal , urinary retention

Prostatic hyperplasia, chronic constipation

Angl-closure glucoma, Phaeochromocytoma

Indication

Anxiety

Dosage

Adult 30mg daily in divided doses up to 100mg daily in severe conditions

Elderly/ debilitated - dose reduction may be required

Contraindicated for use during pregnancy and lactation.

Observe caution if required to be used