Tricylic Compounds include-
      Tertiary amines - Amitriptyline,Clomipramine,Doxepin,Imipramine,Trimipramine
      Secondary amines - Amoxipine, Desipramine, Nortriptyline,Portriptyline
      Refer - Amitriptyline

Impairs antihypertensive effect with guanethedine,methyl dopa and methanidine. Potentiates hypertension produced by sympathtomimetics with MAOIs. Reduced plasma levels with barbiturates Raised levels with methylphenedate. Alcohol potentiates sedative effect.

Depression

     Tricylic Compounds include-
      Tertiary amines - Amitriptyline,Clomipramine,Doxepin,Imipramine,Trimipramine
      Secondary amines - Amoxipine, Desipramine, Nortriptyline,Portriptyline
      Refer - Amitriptyline

Agranulocytosis,thrombocytopenia. Drowsiness,orthostatic hypotension and tachycardia(elderly), Headache,peripheral neuropathy tremor,ataxia,seizures, tinnitus, Confusion/delerium(elderly)

Metallic taste,stomatitis, Gastric irritation, Nausea and vomiting, Allergic skin reactions.

Recent M.I.,cardiac arrhythmias,heart block.

Special precautions:

Mania,severe liver disease,narrow angle glaucoma.

Indications:

Depression

Dosage:

Adult- initially 50 -75 mg/day in divided doses. Increase if necessary to 150 mg/day. may be given in divided doses or as a single dose at night

Do not exceed 200mg/day . Elderly - initial 50 -75 mg daily increased gradually Max 100mg daily

Refer- Amitriptyline 

Refer amitriptyline.

Not reported.

Refer amitriptyline