May antagonise antihistamines. No significant drug interactions have been reported

Menieres syndrome Vertigo, Tinnitus

Mild skin and GI disturbances.

Ocassionally,headache, dizziness,insomnia. Nausea, dyspepsia, headaches, drowsiness, Abdominal cramps, dizziness

Phaeochromocytoma.Neonates.

Contraindicated in bronchial asthma, peptic ulceration, urticaria and rhinitis

Special precautions:

Active peptic ulcer,bronchial asthma,pregnancy

Betahistine is excreted in the milk of nursing mothers in concentrations similar to that found in plasma. Not recommended for children and neonates.

Indication-

Menieres syndrome,

Vertigo, Tinnitus

Dosage-

Oral : 8mg to 16mg three times a day. after meals

Maintenance - up to 24-48mg daily

Not recommended during pregnancy and nursing woman.

Not recommended for children and neonates

Pharmacology:

Molecular structure and pharmacoilogical actions of betahistine is similar to that of histamine, although its pharmacological actions are less potent than that of histamine.

Pharmacokinetics:

Following oral administration, betahistine is completely absorbed and peak plasma concentrations reached after 1 hour. Elimination studies show that 85- 90% of betahistine is eliminated in urine over 56 hours.Little or no binding of betahistine to either serum albumin or other plasma proteins have been reported.

Tablets to be taken after meals

Not recommended for use during pregnancy and lactation.

Not recommended for use on children and neonates.