Drug Information

Updated On: 27-02-2024

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Phenacemide- @ Anticonvulsant

Drug Name:
Phenacemide- @ Anticonvulsant

List Of Brands:

PHENURONE *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

Drug Interaction:

Hydantoins- serum hydantoin levels and half-life may be decreased by phenacemide.

Indication:

Severe epilepsy

ANTICONVULSANTS INCLUDES - BARBITURATES - OXAZOLIDINEDIONES- MISCELLANEOUS- Phenobarbitone Paramethadione Lamotrigine Trimethadione Primidone HYDANTOINS- Valproic acid Phenytoin BENZODIAPINES- Cabamazepine Mephenytoin Clonazepam Phenacemide Ethotoin Clorazepate Felbamate Diazepam Gabapentin SUCCINIMIDES- Ethosuximide Methsuximide Phensuximide REFER PHENYTOIN SODIUM -

Adverse Reaction:

GI disturbances, including anorexia, and weight loss. Drowsiness, headache, insomnia,dizziness, paresthesias. Abnormal urinary findings(including a rise in serum creatinine ). Psychic changes, skin rash, hepatitis.

Contra-Indications:

None reported

Special precautions: Toxicity and severe side effects. Behavioural effects- caution while treating patients who have shown personality disorders. Perform complete blood counts before initiating therapy, and at monthly intervals thereafter. Renal effects. hepatic function impairment.

Dosages/ Overdosage Etc:

Indications: Severe epilepsy

Dosage:

Phenacemide may produce serious toxic effects,, therfore keep the dosage at the minimum amount necessary to acheive therapeutic effects.

Adults- Starting dose- 1.5g/day administered in 3 divided doses of 500mg each. After the first week if seizures are not controlled and the drug is well tolerated, an additional 500mg may be taken upon arising. In the third week, if necessary, the dose may be further increased by 500mg at bedtime.

Children (5 to 10 years)- give approx 1/2 the adult dose at the same intervals as for adults

Patient Information:

1. Notify physician, if jaundice, abdominal pain, pale stools, darkened urine, fever,

sore throat, mouth sores, unusual bleeding or bruising, loss of appetite or skin rash.

2. May produce drowsiness or dizziness; patients should observe caution while driving or

performing other tasks requiring alertness, coordination or physical dexterity.

Ref - USP PDI Vol II 17th Edition (1997)

PHENACEMIDE - Systemic

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

phenacemide or any other anticonvulsant medicines in the past.. Also tell

your healthcare care professional if you are allergic to any other substances

such as foods. preservatives or dyes.

2.Pregnancy-

Phenacemide has been reported to cause birth defects when taken by the

mother during pregnancy. However this medicine may be necessary to

control seizures during pregnancy. Be sure your have discussed this

with your doctor.

3. Breast-feeding-

It is known not whether this medicine passes into breast milk.

4.Children-

Although there is no specific information comparing use of phenacemide

in children with use in other age groups, this medicine is not expected

to cause different side effects or problems than it does in adults.

5.Older adults-

Although there is no specific information comparing use of phenacemide

in the elderly with use in other age groups, this medicine is not expected

to cause different side effects in older people than those produced in

younger adults.

6. Other medicines-

Tell your doctor if you are using any of the following -

Other anticonvulsants- use of phenacemide may increase the chance of

side effects

7. Other medical problems-

Make sure you tell your doctor if you have any other medical problems

especially-

Blood disease or

Kidney diseaase or

Liver disease or

Personality disorder - (mental illness) - phenacemide may make the

condition worse

Pharmacology/ Pharmacokinetics:

Pharmacology: In animals, phenacemide in doses well below those causing neurological signs elevates the threshold for minimal elctroshock convulsions and abolishes the tonic phase of maximal electroshock seizures.

Pharmacokinetics: Phenacemide is well absorbed from the intestine and is degraded by the liver.

Pregnancy and lactation:

Pregnancy: Phenacemide can cause fetal harm if administered to pregnant woman. If phenacemide is used during pregnancy or if the patient becomes pregnant while taking the drug, appraise of the potential hazard to the fetus.

Lactation: Because of the potential for serious adverse reactions, decide whether to discontinue the drug or discontinue nursing taking into account the importance of the drug to the mother.

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