Tetrabenzine should not be given with or within 14 days of discontinuation of MAOI therapy. Blocks action of reserpine

Decreases effects of levodopa or worsens parkinsonism. Increased risk of extrapyrimidal side effects when given with amantadine, metoclopromide, Antipsychotics

Drowsiness Extrapyrimidal symptoms, Parkinsonism, depression, Orthostatic hypotension GI disturbances Neuroleptic malignant syndrome NMS

Lactation

Special precautions-

May exacerbate symptoms of parkinsonism Caution to be excercised when driving or performing skilled tasks Pregnancy

Movement disorders

Dosage-

Adult- initially 12.5mg bid, increased gradually to 12.5 to 25mg tid Max - 200mg daily. If no improvement at max. dose for 7 days, drug unlikely to be of benefit

Elderly- 12.5mg daily increased gradually Moderate to severe tardive dyskinesia

Adult- initially 12.5 mg increased gradually according to response.

Contraindicated for use during pregnancy and lactation Observe caution if required to be used