NSAIDs include-

Propionic acid- Fenoprofen, Flurbiprofen, Ibiprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin

Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates

(anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams- Piroxicam

Refer- Ibuprofen

Increases blood levels of lithium and digoxin, Inhibits diuretics but potentiates potassium sparing diuretics. Increases toxicity of methotrexate. Lowers serum level concentration of salicylates.

Perforation of gastric ulcers,GIT haemorrhage,blood dyscrasias and anapylaxis(rare) GI disturbances, headache, dizziness, rash, pruritis, peripheral oedema.

GI bleeding. Peptic ulcer. Abnormalities of liver and kidney function.

Peptic ulcer,hypersentivity to diclofenac in patients in whom diclofenac sodium, aspirin or other drugs with prostagladin synthetase inhibiting activity, may induce attacks of asthma or acute rhinitis.

Special precautions:

Patients with history of GI ulceration,hematemisis, impaired hepatic, cardiac or renal function, allergic reaction in patients with history of cardiac decompensation, hypotension and in pregnancy.

Indications:

Rheumatoid arthritis

Dosage:

Osteoarthritis - 100 to 159 mg/day in divided doses. Rheumatoid arthritis- 150 to 200 mg/day in divided dose.

Refer- Ibuprofen

1. NSAIDs can cause discomfort and rarely more serious side effects such as GI bleeding which may result in hospitalisation and even fatalities.

2.Avoid aspirin and alcoholic beverages while taking medication.

3. If GI upset occurs, take with food, milk or antacids. For GI upset with tolmetin, use antacids other than sodium bicarbonate.

4. Notify physician, if skin rash, itching, visual disturbances, weight gain, edema occurs

5. Mefanamic acid and metclofenate: if rash, diarrhoea, or digestive problem occr discontinue use and consult physician

6. Ibuprofen- Do not take for more than 3 days for fever or 10 days for pain. If these symptoms persists,consult a physican.

Refer NSAIDs- Ibuprofen

Absorption delayed but not significant

Refer NSAIDs- Ibuprofen