Salicylates,Aspirin @ ( *** ) - Other derivatives- (FDC- List )- (2008)

Drug Name:
Salicylates,Aspirin @ ( *** ) - Other derivatives- (FDC- List )- (2008)

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

  + Salicylates  
 
Activated charcoal  
 coadmin. decreases aspirin absorption depending on charcoal dose
 
Ammoniun chloride/ Ascorbic acid   / Methionine    
 urinary acidifiers decrease salicylate excretion
 
Antacids & urinary alkalinizers 
 decrease the pharmacologic effects of salicylates
  Urinary alkalinization increases renal excretion of salicylic acid
   due to decreased tubular reabsorption of un-ionized drug
 
Carbonic acid  inhibitors  
  salicylates intoxification  occurred after coadministration of these 
   agents. Salicylic acid renal renal elimination increased if 
  urine is kept alkaline
 
Corticosteroids
  increase salicylate clearance and decrease serum levels
 
Salicylate +
 
Nizatidine   
 increased serum  salicylate levels ocurred in patients receiving
 high dose of aspirin ( 3.9g/day ) and concurrent nizatidine
                   
Alcohol
  the risk of GI  ulceration increase when salicylates are given 
  concomittantly. Ingestion of alcohol during salicylate therapy may also
   prolong bleeding time.
 
ACE inhibitors  
  antihypertensive effectiveness of these agents  decreased by 
   concurrent salicylate admin.  due to prostagladin inhibition.
   Consider discontinuing salicylates if problems occur
    
Anticoagulants , oral 
  therapeutic aspirin has an additive hypoprothombimiemic effect.
   Impaired platelet function may prolong bleeding time. Use caution
      
Betablockers
   may have their antihypertensive action blunted by concurent salicylate
    admin.  due to prostagladin inhibition.Consider discontinuing 
    salicylates if problems occur         
 
 Heparin
  asprin can increase bleeding risk in heparin anticoagulant patients
 
Loop diuretics
   less effective when given with salicylates in patients with
   compromised renal function or with cirhhosis  with ascites.
 
Methotrexate
  salicylates increase drug levels causing toxicity by interfering with 
  protein binding and renal elimination of antimetobolite
 
Nitroglycerin
   when taken with aspirin, result in unexpected hypotension. 
    If hypotension occurs, reduce nitroglycerin dose
   
NSAIDs
   aspirin  decrease NSAID  serum conc. Concomittant use offers 
   no advantage and significantly increase incidence of GI   effects
 
Probenecid and Sulfinpyrazone  
  salicylates antagonize the uricosuric effect. While salicylates  in large
   doses ( > 3g/day ) have a uricosuric effect, smaller amounts  may 
   reduce the urocosuric effect of these agents 
 
Spironolactone
  salicylates inhibit the diuretic effects. antihypertensive action
  does not appear altered. Effects depend on dose of spirololactone
 
Sulfonylureas and exogenous insulin
 salicylates in dose greater than 2g/day  have a hypoglycemic 
  action, perhaps by altering pancreatic beta cell function.They
   may potentiate the glucose lowering effect of these drugs
 
Valproic acid 
  aspirin displaces the drug from its protein binding sites and may
  decrease its total body clearance, thus increasing the pharmacological
   effect