Drug Interaction:
Penicillamine , antimalarials, immnospressants, cyclotoxics, phenylbutazone, levamisole,
high dose steroids, warfarin, colonidine, propoxyphene,
other DMARDs, aminoglycosides, amphotericin B penicillins, phenytoin, sulphonamides NSAIDs,
acyclovir, alcohol, metal agonists, nephrotics, haemotoxics,
Indication:
Rheumatoid arthiritis inadequately controlled by NSAIDs
Adverse Reaction:
Diarrhea, nausea, Abdominal pain, Ulcerative colitis,
Rashes, pruritis, Stomatitis, alopecia,
Conjuctivitis, Taste disturbances
Blood dyscrasiasis, Nephrotoxic syndrome,
Pulmonary fibrosis,
Photosentivity Lens and corneal deposits
Bone marrow depression
Proteinuria, haematuria GI upset,
Exfolitaive dermatisis. Chloestatic jaundice,
Goid bronchitis, pneumonitis,
Peripheral neuropathy, changes in liver function
Contra-Indications:
Exfoliative dermatitis, SLE, necrotising enterocolitis, pulmonary fibrosis,
severe renal/hepatic dysfunction.
Pregnancy and lactation.
Special precautions:
Haemotological disorders,diabetes.CCF,H/o allergies.
Dosages/ Overdosage Etc:
Contains 29% Gold
Indications:
Rheumatoid arthiritis inadequately controlled by NSAIDs
Dosage:
Adults - 6 mg/day as 3 mg twice daily or 6 mg once daily.
Other Information:
EVIDENCE BASED MEDICINE (MIMS -April 2003)
Pain of Osteoarthiritis
Comparative effectiveness of various interventions
Beneficial
1. Systemic simple analgesics (eg paracetamol for short term pain relief, and improvement in function)
2. Systemic NSAIDs (short term pain relief and improvement in function)
3. Topical agents (short term pain relief)
Likely to be beneficial
1. Education, dietary advice,empowerment and support ( improved knowledge of disease and pain relief)
2. Physical support (pain relief and improvement in function)
KEY POINTS
1. There is no good evidence that NSAIDs were superior to simple analgesics such as paracetamol or to suggest that any one of the many available NSAIDs had greater efficacy in relieving pain of osteoarthritis.
2. One systematic review of randomised controlled trials has found that topical agents provide pain relief in patients with osteoarthritis and offer a non-toxic alternative to systemic drug treatment. However there is no evidence to indicate whether the prescribed agents were superior to less expensive, non-prescribtion drugs over the counter (OTC) alternatives, or to other local treatments such as hot or cold packs.
Patient Information:
Refer gold compounds
Pharmacology/ Pharmacokinetics:
Refer gold compounds
Interaction with Food:
Take with meal or a light snack
Pregnancy and lactation:
Refer gold compounds
