Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants Increaed bradycardia with beta blockers and digoxin.

Increased serum conc. of tizanidine with CYP1A2 inhibitors eg. zileuton, ciprofloxacin and other fluroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aclovir, ticlopodine.

Decreased serum conc. of tizanidine with rifampicin. Use with caution with drugs that prolong QT interval

Drowsiness, fatigue, dizziness, Insomnia, headache, anxiety, Nausea, dryness of mouth, GI disturbances, Hypotension, bradycardia, Muscle pain and weakness, Transcient increase in serum transaminase, Hallucinations, Hepatitis

Severe hepatic dysfunction

Special precautions: Hepatic or renal insufficiency. Children, Elderly Pregnancy, Lactation

Dosage-

Initially 2mg daily as a single dose increasing to 2mg increments at no less than 3-4 days intervals Given in divided doses 3-4 times daily.

Contraindicated for use during pregnancy and lactation Observe caution if required to be administered