Carisprodol has additive effects with alcohol or other CNS depressants

Ibuprofen may reduce excretion of methotrexate, lithium, and baclofen resulting in their toxicity Ibuprofen increases the risks of bleeding in patients on Coumarin-type anticoagulants.

Pain and Inflammation

Carisprodol CNS effects like drowsiness, insomnia, headache, irritability, depressive reactions and ataxia.

Allergic/idiosyncratic reactions may develop within first to fourth dose in patients with no previous contact with the drug.

Manifestations include skin rash, erythema, multiforme, pruritus,eosinophillia, asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, anaphylaoid shock, transcient quardiplegia, dysarthria, agitation, euphoria, confusion and disoreientation.

GI  effects include heartburn, epigastric distress. Ibuprofen GI effects include heratburn, epigastric distress, nausea, vomiting, diarrhea, constipation, and abdominal pain.

CNS effects include dizziness, light-headedness, and headache.

Others include fever, chills, dyspnea, maculopapular eryhthematous and urticarial rashes, neutropenia, agranulocytosis, hemolytoic anemia, blurred vision, and tinnitus.

Hypersensitivity to the drug, aspirin/related drug.

Acute intermittant porphyria Actrive peptic ulcer Brochospastic conditions.

Special precautions:

Excercise caution in administration to patients with compromised liver or kidney function Carisprodol may impair the mental and /or physical abilities required for the performance of hazardous tasks such as driving or operating machinery.

Due caution is necessary and patients are appropriately counselled as regards this.

Pregnancy and lactation: Safety for use in pregnancy has not been established.

Use with caution Carisprodol is excreted in breast milk at concentrations 2-4 times that of maternal plasma. Use with caution.

Not recommended for use in children

Use of carisprodol should be advocated with caution in addition-prone individuals.

Indication-

Pain and Inflammation

Dosage-

FDC tablet of carisprodol 175mg + Ibuprofen 400mg-

1 tablet thrice a day preferably after food.

Carisprodol may impair the mental and /or physical abilities required for the performance of hazardous tasks such as driving or operating machinery.

Excercise caution while performing these hazardous tasks.

Pharmacology:

Carisoprodol Carisoprodol is congener of mebrobamate. The mode of action is not clearly understood, but may be related to sedative properties. It probably relieves muscle spasm by blocking intermeuronal activity and depressing transmission of polysynaptic neurons in the spinal cord and in desending reticular formation.

. The drug has a rapid inset of action(within 30 min) with a sustained effect for about 4-6 hrs, following oral administration. Ibuprofen Ibuprofen is well known nonsteroidal antinflammatory drug which possesses useful analgesic and antipyretic properties.

The analgesic effects of ibuprofen are due to pripheral action and are distinct fromits property as an antiflammatory drug.

The FDC of carisprodol and ibuprofen, because of their primary central muscle relaxant and antiflammatory-analgesic actions respectively, comprehensively and effectively treats muscle spasms, pain, and inflammation associated with acute muscloskeletal conditions.

Pharmacokinetics:

Carisprodol is well absorbed from the GIT. Following oral administration, its effects begin within about 30 min and last for 4-6 hrs.. The drug is metabolised in the liver and execreted in the urine as metabolites, including meprobamate.

It is distributed substantially into the breast milk. Ibuprofen is well absorbed from the GIT and peak plasma levels occur about 1-2 hrs after ingestion.

The drug is 90-99% plasma protein bound and has a half-life of 2 hrs.

It is rapidly excreted in the urine mainly as metabolites and their congugates. their appears to be little, if any, distribution into the breast milk.

Take preferably after food.

Pregnancy and lactation:

Safety for use in pregnancy has not been established. Use with caution Carisprodol is excreted in breast milk at concentrations 2-4 times that of maternal plasma. Use with caution.

Not recommended for use in children