Drug Information

Updated On: 27-02-2024

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Cladribine ( 2-chlorodeoxyadenosine , CdA ) - @ - Antineoplastic

Drug Name:
Cladribine ( 2-chlorodeoxyadenosine , CdA ) - @ - Antineoplastic

List Of Brands:

LEUSTATIN *
CLADRIUM

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

Drug Interaction:

Reports not available

Indication:

Hairy cell leukemia (HCL )

New drugs approved For Marketing by Drug Controller General of India(DCGI )

during the period January 1988 to November 2014

(Ref- IDMA Annual Publication 2015)

Name of Drug Indication Date of Approval

Cladribine Anti-cancer 09-09-2003

Adverse Reaction:

Severe neutropenia 70% Fever 69% Infection 28%

Other adverse experiences reported frequently during the first 14 days after initiating treatment

Fatigue 45% Nausea 28% Rash 27% Headache 22% injection site infection 19%

Contra-Indications:

Hypersensitivity to the drug

Warnings-

Bone marrow suppression- including neutropenia, anemia, and thrombocytopenia

Nephrotoxicity /neurotoxicity - Mild neurotoxicites specially parathesis and dizziness, hav been reported rarely

Deaths- Of 196 HCl ( hairy cell leukemia ) entred in the trials, there were 8 deaths reported following treatment

Pregnancy- Use during pregnancy only if the benefit justifies the potential risk to the fetus

Lactation- Decide whether to discontinue nursing or discontinue the drug taking into account the importance of drug to the mother

Children- Safety and efficacy in children not established

Dosages/ Overdosage Etc:

Indication-

Hairy cell leukemia ( HCL )

Approved by FDA on February 26, 1993

Dosage-

Recommended dose- Single course given by continuous infusion for 7 consecutive days at a dose of .009mg/kg/day

Deviations from this dosage regimen are not adviced

Patient Information:

Cladribine - Systemic

1.Allergies-

Tell your doctor if you are have ever had any unusual or allergic reaction to

cladribine.

2.Pregnancy-

There is a chance that this medcine may cause birth defects if either the male

or female is taking it at the time of conception or if it is taken during pregnancy.

Cladribine has been shown to cause birth defects in mice, and rabbits.

In addition many cancer medicines may cause sterility which could be

permanent.

Although sterility has not been reported with this medicine fertility problems

do occur in male monkeys and the possibility should be kept in mind

It is best to use some kind of birth control while you are receiving

cladribine. Tell your doctor if you think you may become pregnant while

receiving cladribine

3. Breast-feeding-

It is not known whether cladribine passes into breast milk. However, because

this medicine may cause serious side effects, breast-feeding is generally

not recommened while you are receiving it

4.Children-

There is no specific information comparing use of cladribine - in children with use

in other age groups.

5.Older adults-

Many medicines have not been studied specifically in older people. Therefore,

it may not be known whether they work exactly the same way they do in

younger adults, or if they cause different side effects or problems in older people.

Although,there is no specific information comparing use of cladribine in the

elderly with use in other age groups, it is not expected to cause different side

effects or problems in older people than it does in younger adults.

6. Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur.

In such cases your doctor may want to change the dose, or other precautions

may be necessary.

When you are receiving cladribine it is especially important that your doctor

know if you are taking any of the following-

Amphotericin B by injection or

Antithyroid drugs or

Azathioprine or

Cholramphenicol or

Colchicine or

Flucytosine or

Gangiciclovir or

Interferon or

Pilcamycin or

Ziduvudine or

If you have been treated with radiation or cancer medicines- cladribine may

increase the effects of these medicines or radiation therapy on the blood

7. Other medical problems-

The presence of other medical problems may affect the use of cladribine.

Make sure you tell your doctor if you have any other medical problems

especially-

Chickenpox ( including recent exposure ) or

Herpes zoster( shingles) - risk of severe disease affecting other parts of

the body

Gout (history of) or

Kidney stones (history of) - cladribine may increase the levels of uric acid

in the body, which can cause gout or kidney stones

Infection- cladribine may decrease your bodys ability to fight infection

Kidney disease - effects of cladribine may be increased because of

slower removal from the body.

Pregnancy and lactation:

Pregnancy-

Use during pregnancy only if the benefit justifies the potential risk to the fetus

Lactation-

Decide whether to discontinue nursing or discontinue the drug taking into account the importance of drug to the mother

Children-

Safety and efficacy in children not established

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