Contraceptives- Oral include - Ethinyl oestrdiol, norethindione, norgestrel, desogestrel, levonorgesrtrel, medoxyprogesterone, progesterone

Refer Progesterone

Rifampicin, griseofluvin, phenobarbitone and phenytoin and antibiotics like tetracycline, ampicillin, antihistamines, analgesics, and tranquillisers reduce efficacy causing breakthrough bleeding or failure of contraception.

Efficacy potentiated by Vitamin C.

Reduced efficacy of anticoagulants, antihypertensives, oral antidiabetic drugs and antidepressant drugs.

Endometriosis Dysfunctional uterine bleeding Dysmenorrheoa Menstrual irregularities

Thromboembolism: Pulmonary embolism, coronary thrombosis, cerebral thrombosis and haemorrhage, hypertension, liver functions and congenital anamolies

Mental depression, retinal thrombosis, optic neuritis, hyperglycaemia, cataract, alopecia, cholestatic jaundice, porphyria, exacerbration of epilepsy/migraine, breast discomfort, dizziness, nausea, vomiting, dysmenorrhoea, oedema, changes in libido and appetite.

Severe renal function disturbances, iodopathic jaundice of pregnancy, history of severe pruritus or herpes of pregnancy Dubin-Johnson syndrome. Rotors syndrome, pregnancy, undiagnosd vaginal bleeding.

Special precautions:

Hypertension, CVS disease, hepatic impairment, epilepsy.

Endometriosis Dysfunctional uterine bleeding Dysmenorrheoa Menstrual irregularities Endometrosis-

Dosage-

1 tab daily for 6 -12 months

Dysfunctional uterine bleeding 2 - 4 tabs till acute bleeding stops subsequently

daily dose reduced to 1- 2 tabs till a total of 21 days