Hepatic-enzyme inducing drugs like rifampicin, barbiturates and phenytoin have been reported to
increase the rate of estrogen metabolism.

Unopposed estradiol replacement in postmenopausal women may be associated with an
increased risk of endometrial cancer, the magnitude of the risk depending on the dosage and the
duration of treatment.

Other undesirable effects are nausea, vomitting, tender breasts, weight gain, fluid retention,
headache, depression, abdoninal bloating & increase in the size of uterine fibroids
 

Undiagnosed vaginal bleeding. Endometrial hyperplasia, Known or suspected cancer of the
breast in appropriately selected patients being treated for metastatic disease.
Known or suspected estrogen-dependent neoplasia.
Active thrombophlebitis or thrmbo-embolic disorders. Acute liver disease

Special precautions:
Complete medical history should be taken before initiating treatment. Periodic  physical  
examination of blood pressure, breasts, abdomen, and pelvic organs, including pap smear.
Estrogen should not prescribed for more than one year without prior examination
 

1 - 2 tabs daily. Alternately, 1ml i.m. every 3 - 4 weeks

 

Strong skin care products should not used until one hour after apllication of gel