Prednisolone ( *** )- @ Glucocorticoids- (FDC- List )- (July 2003)

Drug Name:
Prednisolone ( *** )- @ Glucocorticoids- (FDC- List )- (July 2003)

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

Glucorticoids include -
Short acting- Cortisone, Hydrocortisone
Intermediate acting - Prednisone, Prednisolone, Triamcinolone, Methylprednisolone
Long acting- Dexamethasone, Betamethasone
Refer- Dexamethasone
 
Interacting drugs - summary
 
 +Corticosteroids
 
Aminoglutethimide + dexamethosone 
  possible loss of dexamethosone-induced adrenal  suppression 
                 
Barbiturates  
   decreased pharmacolgic effects of the corticosteroids metabolism 
    through the induction of hepatic microsomal enzymes
 
Cholestyramine +  Hydrocortisone 
    hydrocortisine AUC decreased
       
Contraceptives Oral
  Hepatic metabolism  decreased by OCs, resulting in
  increased therapeutic effects or toxicity
 
Ephedrine  + Dexamethasone
   a decreased half-life and increased clearance of dexamethsone
   may occur
 
Estrogens
    estrogen coadministration reduce the clearance and 
     increase the elimination half-life of corticosteroids
 
Hydantoins 
   corticosteroids clearance  decreased and the AUC increased
   resulting in reduced therapeutic effects
 
Ketoconazole
  corticosteroid clearance decreased and the AUC increased                          
 
Macrolide Antibiotics  +  Methyl prednisolone
  significant decrease in methylprednisolone clearance has been used 
 to decrease methylprednisolone dose          
 
Rifampicin  
   corticosteroid clearance increased resulting in decreased 
    therapeutic effects
 
Corticosteroids +
 
Anticholinesterases  
  anticholinesterase effect  antagonised in myasthenia gravis
 
Anticoagulants oral 
   anticoagulant dose requirements  reduced. Conversely, 
   corticosteroids may oppose the anticoagulant action.
 
Cyclosporine
    although this combination is therapeutically beneficial for organ 
     transplant,  toxicity may be enhanced
 
Digitalis glycosides 
    coadministratin enhance the possibility ofdigitalis toxicity 
    associated with hypokalemia
 
Isoniazid
   isoniazid serum concentration  decreased
 
Nondepolarising muscle relaxants 
  corticosteroids potentiate, counteract or have no effect on the
  neuromuscular blocking action
 
Potassium depleting  agents eg.diuretics
    observe patients for hypokalemia
 
Salicylates   
     corticosteroids will reduce serum salicylate levels and  decrease
      their  effectiveness
 
Somatrem   
   growth-promoting effect of somatrem  inhibited
             
Theophyllines
    alterations in the pharmacologic activity of either agent occur