Drug Information

Drug Interaction:

Analbolic steroids include-

Oxymetholone, Stanazolol, Oxandrolone, Nandrolone phenpropionate, Nandrolone deconate,

Refer - Nandrolone

Interacting drugs- summary

Anabolic steroids +

Anticoagulants- anticoagulant effect potentiated by 17-alkyl testosterone derivatives ( eg. anabolic steroids ) Avoid this combination.

Sulfonylureas- hypoglycemic action enhanced by methadrostenone Monitor blood glucose and observe patients for signs of hypoglycemia

Drug/Lab interactions-

Glucose tests- Anabolic steroids have altered glucose tolerance tests. Monitor diabetis closely and adjust insulin or oral hypoglycemic dosage accordingly Thyroid function tests - Decrease in protein bound iodine PBI . throxine -binding capacity, radioactive iodine uptake and increase in T 3 uptake by resin, free throxine levels, remain normal.

Indication:

Control of metastatic cancer in women.

Analbolic steroids include- Oxymetholone, Stanazolol, Oxandrolone, Nandrolone phenpropionate, Nandrolone deconate,

Refer - Nandrolone

Adverse Reaction:

Endocrine- Virilization is the most common undesirable effect.

Acne occurs especially in women and prepubertal males.

Anabolioc steroids inhibit gonodotropin secretion

Prebertal males- first signs of virilization are phallic enlargement and increase in frequency of erections

Postpubertal males- acne, inhibition of testicular function with oligospermia, gynecomastia, testicular atrophy, chronic priapism, epididymitis, bladder irritability , change in libido, impotence

Females- hirsutism, acne, hoarseness or deepening of voice, clioral enlargement, change in libido, menstrual irregularities, male-pattern baldness,

Voice changes, hirsutism and clotoral enlargement are usually not reversible even after

prompt discontinuation.

Electrolyte disturbances - retention of sodium, chloride , water potassium, phophates, and calcium, ankle swelling, decreased glucose tolerance

GI - nausea, vomiting, diarrhea, cholestatic jaundice, hepatic necrosis, death, hepatocellular neoplasms and peliosis hepatitis ( long term therapy )

CNS- excitation, insomnia, habituation, depression

Lab test abnormalites-

Liver function tests- BSP retention, increased AST, serum bilirubin, and alkaline phosphates

Blood coagulation tests- may suppresslotting factors, II, V, and X and increase in

prothrombin time.

Miscellaneous- increased creatinine and creatinine excretion, incfreased serum

cholesterol

Contra-Indications:

Hypersentivity to anabolic steroids,

Male patients with prostrate or breast carcinoma, carcinoma of breast in females with hypercalcemia,

nephrosis, pregnancy,

To enhance physical appearance or athelite performance

Warnings-

Athelete peformance is modified by these agents

Seriuos health hazards associated with anabolic steroids minimize any real real or perceived gain

in performance. Adverse effects may be serious and irreversible

Elderly- geriatric patients treated with anabolic steroids may be at an increased risk of development

of prostatic hypertrophy and prostatic carcinoma

Pregnancy- contraindicated because of possible fetal masculinazation

Lactation- Because of potential for serious adverse reactions in nursing infants, decide whether to

continue nursing or discontinue the drug

Children- safety and efficacy in children have not been established

Special precaution:

Virilization in femsale may occur.If amenorrhea or menstrual irregularites develop during treatment,

discontinue the drug.

Leukemia observed in patients with aplastic anemia treated with oxymetholone, but role of

oxymetholone not clear

Edema - with or without congestive heart failue may occur, Concomittant admin, with with an adrenal

steroid or ACTH may increase edema. Use with caution in patientsith cardiac or renal dieesase

Hypercalcemia - may develop both spontaneously and as a rsult of hormonal therapy in women

diseminated breast carcinoma. Perform frequent urie and serum calcium level examin.

Diabetes- Monitor carefully. Tolerance to glucose may be altered.

Seizure disorder- patients may note an increase in seizure frequency

Dosages/ Overdosage Etc:

Indications:

Control of metastatic cancer in women.

Dosage:

Inject deeply IM preferably into the glutal muscle . Adults- 50 to 100mg weekly.

Patient Information:

Nandalone - Anabolic steroids

1. Individual allergy - Tell your doctor, if you have ever had any unusual or allergic reaction to anabolic steroids Also tell your doctor if you are allergic to any other substance, food, or preservatives.

2. Pregnancy - Use of anabolic steroids is nort recommended during pregnancy

3. Breast feeding - It is not known whether anabolic streroids can cause problems in nursing babies. There is little experience with use in mothers who are breast feeding.

4. Children - Anabolic steroids may cause children to stop growing. In addition, they may make male children develop too fast sexually and cause male-like changes in female children.

5. Other medicines - Certain medicines should not be used together due to interactions. However, tell your doctor if you are using any other prescription drugs eg., acetoaminophen, amiadrone, androgens, anti-infectives by mouth, antithyroid drugs, carbamazepene, chloroquine,estrogens, gold salts, methyl dopa, oral contraceptives, phenytoin, valproic acid, anticoagulants.

6. Other medical problems - Tell your doctor, if you have any other medical problems eg. breast cancer, diabetes mellitus, enlarged prostrate, heart or blood vessel disease, kidney disease, liver disease.

7. Dose - Take this medicine as directed by your physician.

8. Missed dose - Do not miss any doses. Take your missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. 8. Storage - Keep out of reach of children. Do not store in the bath room, near the kitchen sink or in damp places. Heat or moisture may cause the medicine to break down.

9. Outdated medicines - Do not keep outdated medicines or medicine no longer needed. Be sure that any discarded medicine is kept out of reach of children.

10. Side effects - Check with your doctor immediately if any of the side effects occur. Males and females- yellow eyes or skin, bone pain, nausea, vomiting, sore tongue, swelling of feet or lower legs, unusual bleeding, unusual weight gain.

Pregnancy and lactation:

Elderly-

geriatric patients treated with anabolic steroids may be at an increased risk of development of prostatic hypertrophy and prostatic carcinoma

Pregnancy-

contraindicated because of possible fetal masculinazation

Lactation-

Because of potential for serious adverse reactions in nursing infants, decide whether to continue nursing or discontinue the drug

Nandrolone- @ Anabolic steroids

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation