Drug Information

Updated On: 18-11-2024

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Triamcinolone @ ( *** ) - Glucocorticosteroid

Drug Name:
Triamcinolone @ ( *** ) - Glucocorticosteroid

List Of Brands:

LEDERCORT-N OINT
KENACORT INJ
KENOCORT ORAL PASTE
KENALOG-S EYE
TURBOCORT
LEDERCORT
LEDERCORT OINT

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Glucorticoids include -

Short acting- Cortisone, Hydrocortisone

Intermediate acting - Prednisone, Prednisolone, Triamcinolone, Methylprednisolone

Long acting- Dexamethasone, Betamethasone

Refer- Dexamethasone

Interacting drugs - summary

+Corticosteroids

Aminoglutethimide/dexamethosone +

possible loss of dexamethosone-induced adrenal suppression

Barbiturates

decreased pharmacolgic effects of the corticosteroids metabolism

through the induction of hepatic microsomal enzymes

Cholestyramine/ Hydrocortisone+

hydrocortisine AUC decreased

Contraceptives Oral-

Hepatic metabolism decreased by OCs, resulting in

increased therapeutic effects or toxicity

Ephedrine /Dexamethasone+

a decreased half-life and increased clearance of dexamethsone

may occur

Estrogens

estrogen coadministration reduce the clearance and

increase the elimination half-life of corticosteroids

Hydantoins

corticosteroids clearance decreased and the AUC increased

resulting in reduced therapeutic effects

Ketoconazole

corticosteroid clearance decreased and the AUC increased

Macrolide Antibiotics/ Methyl prednisolone +

significant decrease in methylprednisolone clearance has been used

to decrease methylprednisolone dose

Rifampicin

corticosteroid clearance increased resulting in decreased

therapeutic effects

Corticosteroids +

Anticholinesterases

anticholinesterase effect antagonised in myasthenia gravis

Anticoagulants oral

anticoagulant dose requirements reduced. Conversely,

corticosteroids may oppose the anticoagulant action.

Cyclosporine

although this combination is therapeutically beneficial for organ

transplant, toxicity may be enhanced

Digitalis glycosides

coadministratin enhance the possibility ofdigitalis toxicity

associated with hypokalemia

Isoniazid

isoniazid serum concentration decreased

Nondepolarising muscle relaxants

corticosteroids potentiate, counteract or have no effect on the

neuromuscular blocking action

Poatssium depleting agents eg.diuretics

observe patients for hypokalemia

Salicylates

corticosteroids will reduce serum salicylate levels and decrease

their effectiveness

Somatrem

growth-promoting effect of somatrem inhibited

Theophyllines

alterations in the pharmacologic activity of either agent occur

Indication:

Adrenocortical insuffciency, rheumatic disorders, dermatological disorders, bronchial asthma.

Adverse Reaction:

Acute adrenal insufficiency may be precipitated by infection trauma, in patients on long term corticosteroid therapy.

Cushings syndrome, growth retardation in children, osteoporosis and vertebral compression fractures.

Peptic ulceration, haemorrhage and perforation, glaucoma,hyperglycaemia.

GI upsets, nocturia, increased appetite, obesity, facial rounding, increased fragility of skin,

behavioural changes.

Topical applications to skin: Systemic absorption if applied to large areas,broken skin under

occlusive dressing.

Intra articular injection: Aseptic bone necrosis.

Inhalation: Cough, irritation, swallowed inhalation may cause epigastric pain.If no releif with usual dose symtoms may be aggrevated due to hypoxia.

Contra-Indications:

Local/systemic fungal infections,septic arthritis,herpes simplex,hypersens,pregnancy peptic ulcer.

Special precautions:

Infection near injection site, diabetes, hypertension, CVS disease, renal impairment, glaucoma, elderly.

Dosages/ Overdosage Etc:

Indications:: Adrenocortical insuffciency, rheumatic disorders, dermatological disorders, bronchial asthma.

Dosage:: Respiratory disease - 16 to 48 mg/day.

Patient Information:

Refer- Dexamethasone

Pharmacology/ Pharmacokinetics:

Refer- Dexamethasone

Interaction with Food:

Refer Dexamethsone

Pregnancy and lactation:

Refer Dexamethsone

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