Triamcinolone @ ( *** ) - Glucocorticosteroid

Drug Name:
Triamcinolone @ ( *** ) - Glucocorticosteroid

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

Glucorticoids include -
Short acting- Cortisone, Hydrocortisone
Intermediate acting - Prednisone, Prednisolone, Triamcinolone, Methylprednisolone
Long acting- Dexamethasone, Betamethasone
Refer- Dexamethasone
 
Interacting drugs - summary
 
 +Corticosteroids
 
Aminoglutethimide/dexamethosone +
 possible loss of dexamethosone-induced adrenal  suppression               
 
Barbiturates
   decreased pharmacolgic effects of the corticosteroids metabolism 
   through the induction of hepatic microsomal enzymes
 
Cholestyramine/  Hydrocortisone+  
 hydrocortisine AUC decreased 
 
Contraceptives Oral-
 Hepatic metabolism  decreased by OCs, resulting in
 increased therapeutic effects or toxicity
 
Ephedrine /Dexamethasone+  
 a decreased half-life and increased clearance of dexamethsone
 may occur
 
Estrogens
 estrogen coadministration reduce the clearance and 
 increase the elimination half-life of corticosteroids
 
Hydantoins 
  corticosteroids clearance  decreased and the AUC increased
   resulting in reduced therapeutic effects
 
Ketoconazole
  corticosteroid clearance decreased and the AUC increased                          
 
Macrolide Antibiotics/  Methyl prednisolone +   
 significant decrease in methylprednisolone clearance has been used 
  to decrease methylprednisolone dose          
 
Rifampicin 
 corticosteroid clearance increased resulting in decreased 
  therapeutic effects
 
Corticosteroids +
 
Anticholinesterases  
 anticholinesterase effect  antagonised in myasthenia gravis
 
Anticoagulants oral
  anticoagulant dose requirements  reduced. Conversely, 
  corticosteroids may oppose the anticoagulant action.
 
Cyclosporine 
   although this combination is therapeutically beneficial for organ 
   transplant,  toxicity may be enhanced
 
Digitalis glycosides
 coadministratin enhance the possibility ofdigitalis toxicity 
   associated with hypokalemia
 
Isoniazid
  isoniazid serum concentration  decreased
 
Nondepolarising muscle relaxants 
 corticosteroids potentiate, counteract or have no effect on the
 neuromuscular blocking action
 
Poatssium depleting agents eg.diuretics   
 observe patients for hypokalemia
 
Salicylates   
 corticosteroids will reduce serum salicylate levels and  decrease
 their  effectiveness
 
Somatrem
 growth-promoting effect of somatrem  inhibited
             
Theophyllines
   alterations in the pharmacologic activity of either agent occur