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Updated On: 27-02-2024

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Urofollitropin(Menotrophin) @

Drug Name:
Urofollitropin(Menotrophin) @

List Of Brands:

METRODIN INJ
PREGNORM INJ
MENODAC INJ
FOLLITEC

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

Drug Interaction:

Increased risk of ovarian hyperstimulation syndrome with drugs with LH activity

Indication:

Induction of ovulation in patients with polycystic ovarian syndrome

Adverse Reaction:

Nausea, vomting Joint pain, Ovarian hyperstimulation syndrome Adrenal torsion Mild to moderate ovarian enlargement Abdominal pain Ovarian cysts Local reaction at inj site Headaches Haemoperitoneum Benign & malignant ovarian neoplasms Ascites, pleural effusion Hypovalemia Thromboembolic disorders Weigh gain Acne and gynaecomsatia in men Ovarian cysts rupture Intraperitoneal haemorrhage

Contra-Indications:

Pregnancy, Ovarian cysts or enlargement not due to ploycystic syndrome Primary ovarian failure Organic intracranial lesion eg pituitary tumor Uncontrolled thyroid & adrenal dysfunction Presence of any cause of infertility other than anovulation Abnormal bleding of undetremined origin

Special precautions:

May result in multiple pregnancies Abnormal genital bleeding Hormone sensitive malignancies Ovarian cysts not caused by polycystic ovarian syndrome Exclude & treat other causes of fertility eg pitutiary or hypothalamic lesions Adrenal or thyroid disorders & hyperprolactinemia

Dosages/ Overdosage Etc:

Indications:

Induction of ovulation in patients with polycystic ovarian syndrome

Dosage:

Initial dose - 75 IU/day IM urofollitropin, for 7 to 10 days followed by 5000 to 10000 units of HCG, one day after urofollitropin dose.

Patient Information:

1. Prior to therapy, inform patients of the following; duration of treatment, and monitoring

required.

2. Inform patients of the possible adverse reactions, risks of multiple births.

Ref - USP PDI Vol II 17th Edition (1997)

UROFOLLITRIPTOPIN - SYSTEMIC

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

urofollitropin. Also tell your healthcare care professional if you are allergic

to any other substances such as foods. preservatives or dyes.

2.Pregnancy-

If you become pregnant as a result of using this medicine, there is an increased

chance of a multiple pregnancy

3. Other medicines-

Tell your doctor if you are using any other prescription or non-prescription

(Over-the counter) OTC medicine.

4. Other medical problems-

The presence of other medical problems may affect the use of urofollitropin..

Make sure you tell your doctor if you have any other medical problems

especially-

Cyst on ovary - urofollitropin can cause growth of cysts on the ovary

Unusual vaginal bleeding- some irregular vaginal bleeding is a sign

that the endometrium is growing too rapidly, possibly of endometrial

cancer, or some hormone imbalances, increase in estrogen production

caused by urofollitropin can make the problem worse. If a hormonal

imbalance is present it should b treated before the beginning of

menotropin therapy

Pregnancy and lactation:

Observe caution for use during pregnancy

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.