High doses of corticosteroids may inhibit growth- promoting effects of somatropin Antagonism with insulin hence dose of insulin to be adjusted.

Growth hormone, severe acute haemorhage from oesophagaeal varices, ulcers.

Hyperthyroidism. Peripheral odema Headache Muscle and joint pain Benign intracranial hypertension Loss of glycaemic control of diabetics

Acute critical illness due to heart or abdominal surgery Multiple accidental trauma or respiratory failure Active neoplasmsms Proliferative or preproliferative diabetes retinopathy Lactation Patients with closed epiphyses Intracranial lesions Patients with Prader- Willi syndrome who are severely obese or severe respiratory impairment Special precautions: Diabetic mellitus. In growth hormone deficiency secondary to treatment of malignant disease pay attention to signs of relapse of malignacy. Monitor thyroid function, benign intracranial hypertension DM may require dose reduction in Insulin Pregnancy - Discontinue treatment if there is evidence of tumor groth Monitoring in patients with scoliosis is recommended due to risk of progression of scoliosis

Indications:

Growth hormone, severe acute haemorhage from oesophagaeal varices, ulcers.

Dosage:

Individualise dosage. Upto 0.06 mg/kg(0.16 IU/kg)SC OR IM,3 times/week is recommended.

Storage: Before reconstitution- Store vials and diluent at 2C TO 8C.

Avoid freezing.

After reconstitution- stable for 14 days if stored in a refrigerator at 2 TO 8C. .

Pregnancy - Discontinue treatment if there is evidence of tumor growth Contraindicated for use during lactation Observe caution