Sulfonylureas- include

First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide

Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide

Refer Chlorpropamide

Diabetes not responsive to diet 

Sulfonylureas- include-

First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide

Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide

Refer Chlorpropamide

Refer Chlorpropamide-

Refer Chlorpropamide-

Diabetes not responsive to diet

Dosage:

Initial- 250mg to 1.5g/day. Patients on less than 1g daily can be controlled with daily dose.

Missed dose

1. If you miss a dose of this medicine, take it as soon as possible

. 2. However, if it is time for your next dose, skip the missed dose and go back to your regular dosing schedule.

3. Do not double doses.

Sulfonylureas- include-

First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide

Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide

Refer Chlorpropamide

1. Patients must receive full and complete instructions about the nature of diabetes.

2. Strict adherence to prescribed diet, an excercise program personal hygiene and avoidance of infection are essential

3. It is important to teach patients to self-monitor blood glucose

4. Do not discontinue medication except on advice of a physicain

5. May cause GI upset, may be taken with food. take glipizide , 30 minutes before a meal to increase effectiveness.

6. Avoid alcohol (disulfram reaction and interference with blood sugar control ) and salicylates except on professional advice

7. Monitor urine for glcose and ketones as prescribed, monitor blood glucose as prescribed.

8. Notify physician if any of the following occurs- Hypoglycemia- fatigue, excessive thirst or urination, profuse sweating, numbness of extremities Hypoglycemia- excessive thirst or urination, urinary glucose or ketones Other- sore throat, rash, unusual bruising, or bleeding

Refer Chlorpropamide-

Refer Chlorpropamide-