Loop diuretics include- Furosemide, Bumetamide, Ethacrynic acid, Torsemide
Refer Furosemide
 

Diuretic


Loop diuretics include- Furosemide, Bumetamide, Ethacrynic acid, Torsemide
Refer Furosemide

 

Ethacrynic acid

GI- anorexia, nausea, voimiting, diarrhea, pancreatitis ( acute) jaundice, discomfort, pain, sudden watery profuse  diarrhea, GI bleeding, dysphagia.

Hematologic- severe neutropenia has occurred in a few critically ill patients also receiving agents known to produce this effect.
 Rare instances of Henoch-Scoenlein purpura have occured in patients with rheumatic herat diseases.Thrombocytopenia , agranulocytosis

Miscellaneous- fever,chills, hematurai, apprenhension, confusion, fatigue, malaise,    acute gout,sense of fullness in the ears, abnormal liver function tests,  in seriously             ill patients on multiple drug  therapy that included ethacrynic acid (rare) vertigo,            headache, blurred vision, tinnitus, hearing loss (irreversible ) rash occassionally            ,local iritation and pain have occured in parentral use,hyperuricemia, hyperglycemia.

 Acute symptomatic hypoglycemia with convusions occurred in two uremic patients          who received  above doses above those receommended.



 

Refer Furosemide

Diuretic


Dosage:
Give minimally effective dose(usually, 50 to 200mg daily) on a continous or intermittant dosage
schedule to produce gradual weight loss of 2.2 to 4.4kg/day. Adjust dose in 25 to 50mg
increments.
Children- Initial dose is 25 mg. make careful increments of 25mg to acheive maintenance.
 

Hyperglycemia-  ( 1681 )

Glucose intolerance
 

Drugs causing adverse reactions-  ( 386 )

1. Corticosteroids
2. Oral contraceptives
3. Chlorthalidone
4. Ethacrynic acid
5. Thiazides
6. Furosemide
7. Diazoxide
8. Growtrh hormone

Loop diuretics

1. May cause GI upset, take with food or milk
2. Drug will increase urination, take early in the day
3. Notify physician if muscle weakness , cramps, nausea, or dizziness occur
4. Orthostatic hypotension may occur, get up slowly
5. Diabetes mellitus patients- may increase blood glucose levels, affecting urine glucose tests.
6. Photosentivity  may occur in some patients. Cution patients to take protective measures
    (ie Sunscreens, protective clothing) against exposure to ultraviolet light or sunlight
7. Hypersensitivity patients should avoid medications that may increase blood pressure, including  OTC products for  appetite suppression and cold symptoms