Thiazides and related diuretics include-

Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide, Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide

Refer Hydrochlorthiazide- Thiazide and related diuretics

Increased toxicity of cardiac glycosides due to hyperkalemia produced by chlorothiazide.

Combination with antihypertensives can lead to a more pronounced fall  in B.P.

NSAIDs decrease natriurectic effect of chlorothiazide. It partially antagonises action of antidiabetics and drugs used in the treatment of gout.

Causes severe hyperglcaemia when combined with diazoxide.

Delays lithium excretion leading to lithium toxicity.

Bioavailabilty increased by coadministration of propantheline and reduced by metoclopramide.

Edema and Hypertension

Thiazides and related diuretics include-

Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide, Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide

Refer Hydrochlorthiazide- Thiazide and related diuretics

Rarely acute pancreatitis, serious ventricular arrhythmias, in digitalised patients.

GI disturbances, dizziness, headache, parasthesia,

Weakness, visual disturbances, blood dyscrasias, Jaundice, hypersensitivity,

Postural hypertension, Hyperglycaemia, glycosuria,

Hypokalaemia (drowsiness, weakness), Hyponatraemia,

Photosensitivity, hyperuricaemia,

Electrolyte imbalance,.

Hypersens, anuria, or severe oliguria,

sodium and fluid depletion, hypercalcaemia, lactation,

concurrent lithium therapy.

Special precautions:

Pregnancy.

Indication-

Edema and Hypertension

Dosage:

Adults- 0.5 to 1g once or thwice a day.,orally or IV. Reserve IV route for patients unable to take oral medication or emergency situations.

Thiazide diuretics

1. May cause GI upset, may be taken with food

2. Drug will initially increase urination which should subside after a few weeks, take early during the day or as directed

3. Notify physician, if muscle pain,weakneess or cramps, nausea, vomiting, restlessness, excess thirst, tiredness, drowsiness, increased heart rate or pulse, diarrhea, or dizziness occurs

4. May cause photosensitivity (sensitivity to sunlight). Avoid prologed exposure to the sun and other ultraviolet light. Use sunscreens and wear protective clothing until tolerance is determined

5. May increase blood sugar levels in diabetes

6. Do not drink alcohol or take other medications without physicians approval, this includes nonprescription medicines for appetite control, asthma, colds, cough,hay fever or sinus

7. Do not interrupt , discontinue or adjust the dose, even if feeling well. Follow physicians instruction regarding missed dose.

Refer Hydrochlorthiazide- Thiazide and related diuretics

Take with food