Drug Interaction:
Potentiates oral anticoagulants,methotrexates and phenytoin. Potentiates antidiabetic effect of sulphonylureas. Action antagonised by p-aminobenzoic acid and procaine group of local anaesthetics.
Indication:
Mild to moderate infections
Adverse Reaction:
Stevens-Jhonsons syndrome, agranulocytosis, aplastic anaemia. GI syndrome. Hypersensitvity skin reactions, renal impairment, lumbar pain, haematuria, oliguria, anuria and crystallisation. Thrombocytopenia, leucopenia, eosinophillia. Hypoglycaemia, hypothyroidism, jaundice in new born.
Contra-Indications:
Sensitivity to sulphanomides. Pregnancy at term, severe renal/hepatic impairment, porphyria.SLE . Infants below 2 months.
Special precautions:
Renal insufficiency, elderly, blood dyscrasias. G6PD deficiency. AIDS.
Dosages/ Overdosage Etc:
Indications:
Mild to moderate infections
Dosage:
Adults- 0.5 to 1 g 3 to 4 times daily.
Children and infants more than 2 months - 30 to 40 mg/kg/day in divided doses.