Neostigmine Methylsulfate - @ -Urinary Cholinergics
Drug Name:Neostigmine Methylsulfate - @ -Urinary Cholinergics
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Pregnancy and lactation
Drug Interaction:
Reports not available
Indication:
Prevention and treatment of postoperative distention and urinary retention
Adverse Reaction:
Side effects are due to exagegerated pharmacological effects, salivation and fasciculation are most common.
CNS - dizziness, convulsions, loss of conciouness, headache, weakness, dysarthia, miosis, visual changes Cardiovascular - cardiac arrhythmias ( bradycardia, tachycardia, AV bolck and nodal rhythm ) non spedcific
ECG changes, cardiac arrest, syncope, hypotension
Respiratory- increased oral, pharyngeal and bronchial secretions, dyspnea, respiratory depression, respiratory arrest, bronchospasm.
Dermatogical - rash, urticaria
GI - nausea, emesis, flatulence, icreased peristalisis, bowel cramps, diarrhea Musculoskeletal- muscle cramps, and spasms, arthalgia
Body as a whole - diaphoreisis, allergic reactions, anaphylaxis, urinary frequency
Contra-Indications:
Hypersentivity to neostigmine, peritonitis, mechanical intestinal or urinary tract obstruction
special precautions-
Use with caution inpatients with epilepsy, bronchial asthma, bradycadia, recent coronary oculsion, vagotonia, hyperthyroidism, cardiac arrhythmias or peptic ulcer
Concomittant atropine administration- when large doses are administered prior injection or simultaneous injection of atrpoine sulfate may be advisable Use separate syringes for neostigmine or atropine
Hypersensitivity - have atropine and antishock medication immediately avialable
Pregnancy- Give to pregnant women only if needed
Lactation- Because of potential serious adverse reactions to the nursing infants, decide whether to discontinue nursing or to discontinue the drug depending on importance of the drug to the mother
Children -Safety and efficacy for use in childen is not established
Dosages/ Overdosage Etc:
Prevention and treatment of postoperative distention and urinary retention
Dosage-
1 ml of of the 1: 4000 solution ( 0.25mg ) Sc or IM as soon as possible after operation, repeat every 4 o 6 hours for 2 to 3 days
Patient Information:
Pregnancy and lactation:
Pregnancy-
Give to pregnant women only if needed
Lactation-
Because of potential serious adverse reactions to the nursing infants, decide whether to discontinue nursing or to discontinue the drug depending on importance of the drug to the mother Children -Safety and efficacy for use in childen is not established
