Sildenafil has no effect on bleeding time when taken alone or with aspirin Since metabolism of sidenafil is medicated by cytochrome P450, the cytocrome P450 inhibitors are likely to reduce sildenafil clearance.

Concomittant administration of sidenafil 100mg and amlodipine 5 or 10mg in hypertensive patients lead to a mean additional blood pressure reduction.

When taken with a high fat meal, the rate of sidenafil adsorption is reduced.

Headache, flushing, dyspepsia, nasal congestion, Uurinary tract infection, abnormal vision, Diarrhea, dizziness, Rash, Respiratory tract infection.

Hypersensitivity Patients concurrently or intermittently using nitrates in any form.

Special precautions:

Sidenafil clearance reduced in severe renal impaired patients. Not indicated for use in women/newborns/children

Safety and efficacy of sidenafil with combinations not established Should not be used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status.

Dosage-

Usual recommended dose is 50mg taken as needed 1 hour before sexual activity. Can be taken anywhere from 4 hours to 30 minutes before sexual activity. Maximum dose is 100mg

Drugs causing adverse reactions- Impaired ejaculation- ( 386 )

1. Guanethidine 2. Debrisoquin 3. Bethanidine 4. Thioridazine

1. Not to be used in patients with cardiovascular ailments

When taken with a high fat meal, the rate of sidenafil adsorption is reduced.