Penicillins include- Natural- Penicillin G, Penicillin V Penicillase -Resistent- Cloxacillin, Docloxacillin, Methicillin, Nafacillin, Oxacillin Aminopenicillins- Amoxicillin, Amoxicillin/Potassium Clavulanate, Ampicillin, Ampicillin/Sulbactum, Becampicillin Extended spectrum- Carbenicilin, Mezlocillin, Piperacillin.Tazobactam sodium, Ticarcillin, Ticarcillin/Potassium clavulanate Refer Penicillin V Potassium

 Pipercillin may inactivate aminoglycosides. Synergistic with cephalosporins, Clearance of pipercillin reduced by probenecid.

Treatment of mixed infections. 

Anaphylactic reactions, rare, prolongation of bleeding time.Leucopenia, eosinophilia, electrolyte and fluid disturbances.

Allergy to penicillins

Special precautions:

Allergy to cephalosporins,pregnancy.

Indication:

Treatment of mixed infections and presumtive therapy prior to identification of causative organisms. Also it may be used as a single drug therapy in some situations where two antibodies are normally used.

Dosage:

Administer IM or IV for serious infections: Give 3 to 4g every 4 to 6 hours as a 20 to 30 minute IV infusion. Maximum daily dosage is 24g/day. Limit IM injection to 2g/site.

Infants and children below 12 years: Dosage not established.

Following doses suggested: Neonates - 100mg/kg/day every 12 hours. Children- cystic fibrosis, 350 to 500mg/kg/day divided every 4 to 6 hours. Other conditions- 200 to 300mg/kg/day divided every 4 to 6 hours..

Refer Penicillin

Refer Penicillin

Refer Penicillin

Refer Penicillin