Cephalexin - Cephalosporins - @ First Generation- (FDC-List)(Dec 1994)
Drug Name:
Cephalexin - Cephalosporins - @ First Generation- (FDC-List)(Dec 1994)
List Of Brands:
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Drugs covered:
1st generation 2nd generation 3rd generation .
Cephalexin Cefaclor Cefixime Cefadroxil Cefamandole Cefoperazone Cephadrine Cefotoxitin Cefotaxime Cephalothin Cefuroxime Ceftizoxime Cephapirin Cefonicid Ceftriaxone Cefazolin Cefmetazole Ceftazidime Cefotetan Ceftibuten Cefprozil Cefepime Cefpodoxime Loracarbef
Refer Cephalosporins
Activity enhanced by aminogycosides.
Indication:
A first generation drug
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Cephalexin IP as monohydrate 07-03-2012
200mg + kanamycin IP as monosulphate
100,000 IU in suspension per 10gm
intramammary suspension
For treatment of clinical mastitis in lactating cows for bacteria susceptible to
the combination of cephalexin and kanamycin such as staphylococcus
Aureus , streptococcus uberis and Escheria Coli.
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Cephalexin anhydrous 250mg+ 30-12-1994
Carbocisteine 150mg per 5ml suspension
2. Cephalexin monohydrate eq.to Cephalexin 500mg/250mg+ 30-12-1994
Carbocisteine 150mg/150mg capsules
3.Cephalexin monhydrate eq.to Cephalexin 125mg/250mg+ 27-01-1995
Bromhexine Hcl eq to Bromhexine 2mg/4mg per 5ml
reconstituted suspension
RTI characterized by excessive or viscid mucous
4.Cephalexin 250mg/500mg + 16-09-1994
Bromhexine Hcl 4mg/8mg capsules
RTI characterised by excessive or viscid mucous
Respiratory tract infections,
otitis media,
skin and structure infections,
GU infections.
Drugs covered:
1st generation 2nd generation 3rd generation .
Cephalexin Cefaclor Cefixime Cefadroxil Cefamandole Cefoperazone Cephadrine Cefotoxitin Cefotaxime Cephalothin Cefuroxime Ceftizoxime Cephapirin Cefonicid Ceftriaxone Cefazolin Cefmetazole Ceftazidime Cefotetan Ceftibuten Cefprozil Cefepime Cefpodoxime Loracarbef
Refer Cephalosporins
Adverse Reaction:
Anaphylactic reactions.
Pain at inj site. Hypersensitivity.
GI disturbances, candidiasis,
Eosinophyllia, nitropenia, thrombocytopenia,
Rise in liver enzymes and blood urea.
Positive Coombs test.
Contra-Indications:
Known hypersens to cephalosporins.
Special precautions:
Hypersens to penicillins. Overgrowth of non-susceptible organisms. Pseudomembranous colotis.
Early pregnancy.
Lactation
Use glucose oxidase or hexokinase methods for blood or plasma glucose tests,
renal failure.
Dosages/ Overdosage Etc:
A first generation drug
Indications:
Respiratory tract infections,otitis media, skin and structure infections, GU infections.
Dosage:
Adults: 1 to 4g/day in divided doses. Usual dose 250mg every 6hours. May need larger doses for more severe infections. If dose is more than 4g/day, use parentral drugs.
Children: 25 to 50mg/kg/day in divided doses. For streptococcal pharyngitis in patients less than 1year for skin structure infection divide total daily dose and give every 12 hours. In very severe infections, double the dose- 75 to 100mg/kg/day in 4 divided doses.
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
Refer cephalosporins
Pharmacology/ Pharmacokinetics:
Refer cephalosporins
Interaction with Food:
May be taken with meals to reduce GI discomfort
Pregnancy and lactation:
Refer cephalosporins
