Drugs covered: 1st generation 2nd generation 3rd generation .

Cephalexin Cefaclor Cefixime Cefadroxil Cefamandole Cefoperazone Cephadrine Cefotoxitin Cefotaxime Cephalothin Cefuroxime Ceftizoxime Cephapirin Cefonicid Ceftriaxone Cefazolin Cefmetazole Ceftazidime Cefotetan Ceftibuten Cefprozil Cefepime Cefpodoxime Loracarbef

Refer Cephalosporins

Concomittant administration with antacids reduces the rate and extent of absorption by approximately 40%.

Probenecid - results in approximately doubling in AUC, increase in peak cefdnir plasma levels, and prolongation in the apparent elimination half life.

Iron supplements and foods fortified with iron-reduce extent of absorption by 80% and 31% respy.

A false positive reaction for ketones in the urine may occur with tests using nitropruside, but not with those using nitroferricynide.

U.S.FDA  APPROVED FROM 01-01-08 TO 31-12-08

 U.S FDA APPROVED  OF DRUGS DURING 2004

Headache, dizziness, weakness, parathesis, fever, chills, nausea, vomiting, diarrhea,

anorexia, glossitis, bleeding, increased AST, ALT, bilirubin, LDH, alkaline phosphatase,

abdominal pain. vaginitis, pruritus, candidiasis, increased blood urea, anemia, eosinophyllia,

rash, urticaria.

Hypersensitivity

Special precautions:

Should be used with caution in individuals with a history of colitis.

In patients with transcient or persistent renal insufficiency (creatinine clearance ml/mim) the total daily dose of cefnidir should be reduced

Caution to excercised during pregnancy, lactation or children( safety not established).

Indication-

Chronic bronchitis, pneumonia

Dosage-

Adults and adolescents age 13 and older.- Chronic bronchitis- 300mg every 12 hours for 10 days or 600mg every 24 hours for 10 days.

Pharmacolgy:

Cefdinir has broad spectrum activity against gram- positive and gram- negative microorganisms.. It has potent activity against gram-positive microorganisms eg staphylococcus sp. It is a bactericidal antibiotic.

Pharmacokinetics:

Maximal plasma cefdinir concentrations occur 2 to 4 hours post-dose following oral administration. Plasma cefdnir concentrations increase with dose. Estimated bioavailabilty of cefdnir capsules is 21% following oral administration of 300mg capsules and 16% following administration of 600mg capsules.Estimated bioavailability of cefdnir suspension is 25%.

Iron supplements and food fortified with iron reduces the extent of absorption.

Caution to be excercised during pregnancy, lactation or children( safety not established).