Drugs covered:

1st generation 2nd generation 3rd generation .

Cephalexin Cefaclor Cefixime Cefadroxil Cefamandole Cefoperazone Cephadrine Cefotoxitin Cefotaxime Cephalothin Cefuroxime Ceftizoxime Cephapirin Cefonicid Ceftriaxone Cefazolin Cefmetazole Ceftazidime Cefotetan Ceftibuten Cefprozil Cefepime Cefpodoxime Loracarbef

Refer Cephalosporins

Potentially nephrotoxic and may enhance nephrotoxicity of Gentamicin & Tobramycin.

Nephrotoxicity potentiated by frusemide & ethacrynic acid.

Probenecid slows tubular excretion,hence can be usefully combined.

Lower/upper respiratory tract infection, ottitis media, skin structure infection, urinary tract infections

Drugs covered:

1st generation 2nd generation 3rd generation .

Cephalexin Cefaclor Cefixime Cefadroxil Cefamandole Cefoperazone Cephadrine Cefotoxitin Cefotaxime Cephalothin Cefuroxime Ceftizoxime Cephapirin Cefonicid Ceftriaxone Cefazolin Cefmetazole Ceftazidime Cefotetan Ceftibuten Cefprozil Cefepime Cefpodoxime Loracarbef

Refer Cephalosporins

A second generation drug

Anaphylactic reaction.

Allergic reactions, pseudomembranous colitis (occasionally) diarrhoea, nausea, vomiting, candidiasis, eosinophillia.

Direct positive coombs test without evidence of haemolytic anaemia can cause difficulties in cross matching blood, or in investigation of infants of mothers treated on this drug.

Transient elevation of serum SGOT/SPT levels.

False positive reaction for urinary glucose.

Known hypersens to cephalosporins/penicillins.

Special precautions:

Penicillin hypersens.

Infants less than 1 month,impaired renal function.

A second generation drug

Indications:

Lower/upper respiratory tract infection, ottitis media, skin structure infection, urinary tract infections

Dosage:

Usual dosage is 250mg every 8hours. In severe infection or those caused by less susceptible organisms, dosage may be doubled.

Children: Give 20mg/kg/day in divided doses every 8 hours. In serious infections caused by less susceptible organisms, administer 40mg/kg/day, with a maximum of 1g/day.

Storage: Refrigerate suspension after reconstitution. Discard after 14 days.

Refer cephalosporins

Refer cephalosporins

Take with or without food

Refer cephalosporins