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Updated On: 27-02-2024

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Roxithromycin - @-Macrolide- (March 1992)

Drug Name:
Roxithromycin - @-Macrolide- (March 1992)

List Of Brands:

ROXEPTIN
ROXID
ROXYROL KID
RULIDE*
RULIDE

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Macrolide antibiotics include-

Azithromycin. clarithromycin, dirithromycin, erythromycin and troleandomycin

Refer- Erythromycin

Interacting drugs- summary

Roxithromycin +

Pimozide / Terefenadine / Astemizole / Cisapride

Roxithromycin inhibits cytochrome P450 enzymes leading to decreased

metabolism resulling in increased serum concentration of these drugs.

Result in prolonged QT intervals, severe ventricular arrhythmias and

sudden death. Avoid concomittant administration of roxithromycin with

terfenadine, astemizole and cisapride.

Warfarin

Although roxithromycin has a lesser inhibiting effect on cytochrome P450

enymes than other macrolide antibiotics, roxithromycin may potentiate the effects of warfarin in severely ill elderly or compromised patients and increase risk of bleeding

Disopyramide

Roxithromycin displaces disopyramide from protein-binding sites in vitro.

Concurrent administration of these drugs in vivo resulted in increased

disopyramide serum concentration. Consequently ECG and if possible

disopyramide levels should be monitored

Midazolam

Roxithromycin may inhibit benzodiazepine metabolism, leading to

increased plasma concentration of benzodiapines toxicirty (CNS depression,

ataxia, lethargy)

Digoxin

Macrolide increases plasma concentration of digoxin resulting in

increased risk of toxicity. Serum dogoxin levels should be carefully

monitored when roxithromycin is added to or withdrawn from therapy

Theophylline

Caution should be excercised with patients receiving concomittant

theophylline therapy as roxithromycin may increase theophylline levels,

which lead to theophylline toxicity.

Indication:

Suscepible infections

Macrolide antibiotics include- Azithromycin. clarithromycin, dirithromycin, erythromycin and troleandomycin Refer- Erythromycin

New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing

(Ref- IDMA Publication)

Name of Drug Indication Date of Approval

Roxithromycin Anti-bacterial March 1992

Adverse Reaction:

Anaphylactic reactions.

Nausea,abdominal pain, Diarrhoea, weakness, malaise, anorexia, Constipation, dyspepsia, Flatulance, malaena, Oral candidiasis, Vomiting, dizziness, tinnitus, Headache and vertigo.

Contra-Indications:

Hypersens to roxithromycin

Special precautions:

Liver cirrrhosis, pregnancy

Dosages/ Overdosage Etc:

Suscepible infections

Dosage-

150mg bid or 300mg once daily for 5-10 days in susceptible infectiions

Other Information:

For Availability/supplies

Contact -

1.Indian Drug Manufacturers Association (IDMA)

Phone- 022- 24944624/ 24974308

Fax- 022- 24950723

Email- idma@vsnl.com

Website: www.idma-assn.org

2.Bulk Drug Manufacturers Association (India)(BDMA)

Phone - 040-23703910/ 23706718

Fax- 040-23704804

Email- info@bdmai.org

Website: www.info@bdmai.org

Patient Information:

Refer- Erythromycin

Interaction with Food:

Food taken just before taking the drug reduces absorption but not if taken 15 minutes aftter the dose.

Pregnancy and lactation:

Observe caution when used during pregnancy or lactation

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.