Streptococcus pnemonia 

Most frequent- Abdominal cramps and discomfort (dose related)

Infrequent- Nausea, vomiting. diarrhea Hypersensitivity- Anaphylaxis, urticaria

Hypersensitivity

Special precautions:

Superinfection-Use of antibiotics (especialy prolonged or repeated therapy) may result in bacterial or fungal overgrowth of non-susceotible organisms. Take appropiate measures if this occurs

Warnings

Hepatic effects- Troleandomycin has been associated with an allergic cholestsatic hepatitis. These have reversed on drug discintinuatiuon.

Readministration reproduces hepatoxicity, often within 24 to 48 hours.

Monitor liver function tests and discontinue if abnormalities develop.

Pregnancy- Safety for use during pregnancy has not been established.

Indication:

Streptococcus pnemonia

Dosage:

Continue therapy for 10 days when used for streprococcal infections Adults- 250 to 500mg, 4 times a day. Children- 125 to 250mg every 6 hours

1.Take at evenly spaced intervals during the day, preferably around the clock.

2. Complete full course of therapy.

3. Take until gone

Pharmacology:

Synthetically derived acetylatehyde ester of the macrolide oleandomycin

Pharmacokinetics:

Peak serum levels of 2mcg/ml are attained following a 500 mg dose. serum levels are detected 12 hours later, 20%of the drug is reciverd in the urine. Significant quantities are excreted in the bile.

Pregnancy- Safety for use during pregnancy has not been established.