Reports not available

Potentiates oral anticoagulants, methotrexates and phenytoin. Potentiates antidiabetic effect of sulphonylureas. Action antagonised by p-aminobenzoic acid and procaine group of anaesthetics.

Stevens- Johnsons syndrome, agranulocytosis, aplastic anaemia. GI symptoms, Hypersensitivity skin reactions, renal impairment, lumbar pain, haematuria, oliguria, anuria, and crystallisation. Thrombocytopenia, leucopenia, eosinophilia. Hypoglycaemia, hypothyroidism, jaundice in new born

Sensitivity to sulphonamides, severe renal/hepatic impairment, porphyria, SLE infants below 2 months. Special precautions: Renal insufficiency, elderly, blood dyscrasias, G6PD defienciency, AIDS, pregnancy

Suceptible infections

Susceptible infections Adult- 2-4g /day May increase up to 6g/day Child - 75mg/kg subsequently 150mg mg/kg in divided doses