Drug Interaction:
Interacting drugs- summary
Trimethoprim +
Procainamide
elevated procainamide and NAPA serum levels ccur, possibly resulting
in increased pharmaocologic efects.
Zidovudine
serum levels of zidovudine and its metabolites increased
Trimethoprim + Dapsone or Dapsone + Trimethoprin
increased serum levels of both drugs appear, increasing the
pharmacologic and toxic effects of each drug
Indication:
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Trimethoprim & Sulphadoxine Sept 1973
2.Trimethoprim 160mg + Jan 1979
Sulphamethoxazole 800mg per 3ml inj
3. Trimethoprim 4% w/v + Jul 1974
Sulphadoxime 20% w/v
4. Trimethoprim 80mg + Oct 1976
Sulphamethoxazole 400mg per ml infusion
5. Trimethoprim + Sufamoxole Sep 1975
6.Trimethoprim 40mg + Jul 1970
Sulphamethoxazole 200mg/5ml suspension
7.Trimethoprim 80mg/20mg + Jul 1970
Sulphamethoxazole 400mg/100mg tablet
Uncomplicated UTI due to susecptible strains.
Adverse Reaction:
Pruritus, skin rash, fever, nausea, vomiting, sore mouth.
Contra-Indications:
Hypersens to TMP.Documented megaloblastic anaemia due to folate deficiency.1st trimester of pregnancy.
Special precautions:
In patients with folate deficiency. Patients with impaired renal or hepatic function. Nursing mothers.
Dosages/ Overdosage Etc:
Indications: Uncomplicated UTI due to susecptible strains.
Dosage: Adults- 100 mg every 12 hours or 200 mg every 24 hours for 10 days. Children below 12 years - effectiveness not established.
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
Take full course of therapy
Ref - USP PDI Vol II 17th Edition (1997)
TRIMETHOPRIM- SYSTEMIC
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Trimethoprim. Also tell your healthcare care professional if you are allergic
to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Studies have not been done in humans. Studies in rabbits have shown that
trimethoprim causes a decrease in the number of pregnancies. However,
in the few reports where trimethoprim was taken by pregnant women,
trimethoprim has not been reported to cause birth defects or problems
in humans.
3. Breast-feeding-
Trimethoprim passes into breast milk. However, this medicine has not been
reported to cause serious problems in nursing babies
4.Children-
This medicine has been tested in a limited number of children 2 months of age
or older, and tested in children 12 years of and older. In effective doses this
medicine has not been shown to cause different side effects or problems
than it does in adults.
5.Older adults-
Elderly people may be more sensitive to the effects of trimethoprim. Blood
problems may be more likely to occur in elderly patients who are taking
diuretic along with this medicine.
6. Other medicines-
When you are taking trimethoprim it is especially important that your doctor
know if you are using any of the following-
Anticonvulsants or
Methotrexate or
Pyrimethamine or
Triamterene - use of these medicines with trimethoprim may increase
the chance of side effects affecting the blood.
7. Other medical problems-
The presence of other medical problems may affect the use of
trimethoprim. Make sure you tell your doctor if you have any
other medical problems especially -
Anemia - patients with anemia may have an increased chance of
side effects affecting the blood
Kidney disease- patients with kidney disease may have an increased
chance of side effects
Pharmacology/ Pharmacokinetics:
Pharmacology:
Trimethoprim blocks production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. bacterial biosynthesis of necleic acids and proteins is blocked by trimethoprims interference with normal bacerial metabolism of folinic acid.
Pharmacokinetics:
Oral trimethoprims are rapidly absorbed, mean peak serum levels of approximately 1mcg/ml occur 1 to 4 hours after a single 100mg dose. Trimethoprim is metabolised less than 20%. Half-life is 8 to 10 hours. Elimination is delayed in patients with renal impairment
Interaction with Food:
Reports not available
Pregnancy and lactation:
Pregnancy:
Trimethoprim crosses the placenta and produces effects in fetal and maternal serum in amniotic fluid. No abnormalities in children exposed during first trimester of pregnancy.
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