Fluoroquinolones include the following :

Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin

Refer Ciprofloxacin

Interacting drugs Antacids Didanosine Iron salts Sucralfate Zinc salts Azlocillin ( Ciprofloxacin ) Bismuth sub salicylate ( Enoxacin ) Cimetidine Nitrofurantoin ( Norfloxacin ) Probenecid Caffeine ( Ciprofoxacin, Enoxacin, Norfloxacin) Cyclosporine (Ciprofloxacin, Norfloxacin, Fluroquinolones) Digoxin (Enoxacin ) Hydantoins (Ciprofloxacin ) Anticoagulants Theophyline

Fluoroquinolones include the following :

Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin Refer Ciprofloxacin Interacting drugs Antacids Didanosine Iron salts Sucralfate Zinc salts Azlocillin ( Ciprofloxacin ) Bismuth sub salicylate ( Enoxacin ) Cimetidine Nitrofurantoin ( Norfloxacin ) Probenecid Caffeine ( Ciprofoxacin, Enoxacin, Norfloxacin) Cyclosporine (Ciprofloxacin, Norfloxacin, Fluroquinolones) Digoxin (Enoxacin ) Hydantoins (Ciprofloxacin ) Anticoagulants Theophyline

1. Drink fliuds liberally

2. Do not take antacids containing magnesium or aluminium or products containing iron or zinc simultaneously or within 4 before or 2 hours after dosing.

3. May cause dizziness or lightheadedness. Observe caution while driving or performing other tasks requiring alertness,co-ordination or physical dexterity.

4. CNS stimulation may occur (eg tremor, restlessness, confusion. Use with caution in patients predisposed to seizures or with CNS disorders.

Pharmacology:

The fluroquinolones are synthetic broad- spectrum antibacterial agents related to the other quinolones, nalidixic acid and conoxicin. These agents contain a 6-fuoro and 7-piperazine substituent which enhances their anti-microbial efficacy when compared to nalidixic acid. The fluorine molecule provides increased potency against gram negative organisms and broadens the spectrum to include gram-positive organisms, the pierazine moiety is res[ponsible for antipseudomonal activity.

Food may decrease the absorption of norfloxacin. Food delays the absorption of ciprofloxacin. Food delays rate of absorption of lomefoxacin.

Pregnancy Do not use in pregnant women. There are no adequate and well controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risks to the fetus. Lacation: Norfloxacin was not detected in breast milk following administration of 20mg to nursing mothers; however this was a low dose. Ciprofloxacin is excreted in breast milk,however the amount ingested by the infant appears low. It is known whether lomefloxacin or enoxacin are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, decide whether to discontinue nursing or discontinue the drug, taking into consideration the importance of the drug to the mother. Children: Do not use in children. Safety and efficacy of lomefloxacin, enoxacin and ofloxacin in children below 18 years of age have not been established.