Alcohol increases risk of hepatitis.
Phenytoin, pyridoxine defeciency
Increases risk of neuropathy

 Hepatic disorders
Dose depedendent perpheral neuropathy

Occassiuoal damage to optic nerve
Convulsions or psychoses

Blood dyscrasis
Rheumatic syndrome

LE- like signs
Mild CNS  syndrome

Dermatitis
Joint pain
Pyridoxine defeciency

 

Optic neuritis
Liver damage
Susceptibility to epilepsy

Special precautions-
Test visual functions before treatment is started,monthly f dose exceeds 15mg/kg
Gout
Impaired renal or hepatic function
Monitor blood function in long term use
Chronic alcoholism
Convulsive disorders
Diabetes
Increased risk of liver damage with increasing age
Pregnancy,
Lactation

 

Tuberculosis

1 tab daily

Use contraindicated
Observe caution if required to be administered during pregnancy or lactation