Serious infections caused by strains of canidida or Cryptococcus 

Respiratory arrest, chest pain, dyspnea. Rash,pruritus, urticaria, Photosensitivity. Nausea, emesis,

Abdominal pain, Diarrhea, anorexia, Dry mouth, duodenal ulcer, Haemorhage, hepatic dysfunction, Jaundice, ulcerative colitis, Bilirubin elevation.

Hypersens to the drug

Indications:

Serious infections caused by strains of canidida or Cryptococcus

Dosage:

Usual dosage- 50 to 150mg/kg/day in divided doses at 6 hourly intervals. To reduce or avoid nausea or vomiting, take capsules a few at a time over 15 minutes.

Pharmacology:

Flucytosine has in vitro and vivo activity against Canidida and Crytococcus, but the exact mode is not known

Pharmacokinetics:

Well absorbed after oral use with peak serum levels in 2 hrs. About 80 to 90% of the drug is excreted unchanged in the urine

Pregnancy:

No adequate or well controlled studies studies on pregnant woman. Use only if the potential benefit outweighs the potential risk

Lactation:

Because of the potential serious adverse reaction to the nursing infant, either discontinue nursing or discontinue the drug.