Azole anti-fungals include- Fluconazole, Itraconazole, Ketoconazole, Miconazole, Terconazole

 Interacting drugs- summary

 Miconazole +

Cisapride-                                                                                                                           Ketoconazole inhibits the metabolism of cisapride, resulting in a mean eightfold increase in cisaprides AUC, prolongation of QT interval on the ECG may occur . Concurrent use is contraindicated

Severe fungal infections 

Anaphylactic reaction and cardiac arrest(I/V therapy). Nausea, vomiting, febrile reactions, rash, drowsiness, diarrhoea, anorexia and flushing. I/V administration: Cardiac arryhthmias, phelbitis, pruritis.

Topical(cream & pessaries): Local irritation and sensitivity contact dermatitis.

Hypersens to the drug.

Special precautions:

Discontinue if sensitization or irritation.

Indications:

Severe fungal infections

Dosage:

Adult- 1800 to 3600mg 3 to 4 divided doses daily

Children- less than 1 year old -15 to 30mg/kg/day

Children- more than 1 year upto 12 years- 20 to 40mg/kg/day..

Reports not available.