Drug Information

Indication:

Prevention of premature ovulation in controlled ovarian stimulation followed by oocyte pick-up and assisted reproductive techniques

Adverse Reaction:

Injection site reactions Ovarian hyperstimulation syndrome Headache, nausea Elevated enzyme e.g. ALT , alkaline phosphatase

Contra-Indications:

Moderate to severe renal or hepatic imapirment Post menopause Pregnancy Lactation Extrinsic pedptide hormone Mannitol hypersensitivity

Special pecautions- Repeated ovarian stimulation oe cycles, Active allergic conditions Do not complete gynaecolgical and endocrinal exam first

Dosages/ Overdosage Etc:

Prevention of premature ovulation in controlled ovarian stimulation followed by oocyte pick-up and assisted reproductive techniques 0.25mg once daily by s.c injection into lower abdomen wall given within 96 -120 hours of starting ovarian stimulation with gonodotrophin . Continue upto and inculding day of ovulation injection Alternatively a single s.c. inj on day 7 of ovarian stimulation If ovarian induction is not possible on the 5th day after injection aditionaly inject 0.25mg once daily until day of ovulation

Pharmacology/ Pharmacokinetics:

Ref- Drug Facts And comparisons(2010)

Pharmacology-

GnRH induces the production and release of LH and follicle -stimulating Hormone(FSH)

from the gonadotrophic cells at the anterior pitutary. Because of positive estradiol E2

feedback at midcycle, GnRH liberation is enhanced , resulting in LH surge. The LH surge

induces the ovulation of the dominant follicle , resumption of oocyte meiosis and

subsequently luteinization , as indicated by rising progesterone levels

Pharmacokinetics-

The pharmacokinetics of parameters of single and multiple doses of cetorelix in adult

healthy women are summarized in the following table-

Pharmacokinetic Parameters of Cetrorelix Following 3mg Single or 0.25mg

Single and Multiple (Daily for 14 Days) Subcutaneous Administration

Parameter Single Dose Single dose Multiple Dose

3mg 0.25mg 0.25mg

(n=12) (n=12) (n=12)

Tmax 1.5 1 1

(h) (0.5 to 2) (0.5 to 1.5) (0.5 to 2)

T 1/2 62.8 5 20.6

(h) (38.2 to 108) (2.4 to 48.8) (4.1 to 179.3)

Cmax (ng/mL) 28.5 4.97 6.42

(22.5to 36.2) (4.17 to 5.92) (5.18 to 7.96)

CL

(ml/min*kg) 1.28

Vz 1.16

(l/kg)

Pregnancy and lactation:

Observe caution. Contraindicated for use during pregnancy and lactation

Cetrorelix- Ovulation Stimulant - Sex Hormone

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

Indication:

Adverse Reaction:

Contra-Indications:

Dosages/ Overdosage Etc:

Pharmacology/ Pharmacokinetics:

Pregnancy and lactation:

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