Protien bound levels may be increased during treatment and interfere with the results of thyroid function tests. These efffects may persist for as long as 6 months after discontinuation of therapy

Treatment of intestinal amebiasis

Neurotoxicity,sub-acute optico-myleoneuropathy. Optic neuritis, atrophy and peripheral neuropathy (especially in children given high doses for a long time),

Dermatologic- various forms of skin eruptions ( acneform , papular, pastular, bullae, vegetating or tuberous ioderma ) uticaria, pruritus

GI -abdominal cramps, nausea and diarrhoea, pruritis ani, skin eruptions enlargement of thyroid (due to iodine content). Fever, chills, headache and vertigo.

Topical application: Contact allergy, irritant dermatitis

Hypersensitive to any 8-hydroxyquinoline eg. iodoquinol , iodohydroxyquin or iodine containing preparations, epatic damage

Warning

optic neuritis , optic atropthy and peripheral neuropathy have occured following prolonged high dosage therapy, avoid long term therapy

Special precautions: Renal dysfunction,thyroid disease and neurological disorders. Pregnancy- Safety for use during pregnancy and in nursing mother has not been established

Indications: Intestinal amebiasis.

Dosage: 650mg 3 times daily after meals for 20 days.

Children - 40mg/kg daily(maximum 650mg/dose) in 3 divided for 20 days..

Pharmacology:

Iodoquinol is effective against the trophozolites and cysts of Entomoeba histolytica in the large intestine. Because it is poorly absorbed in the GI tract, the drug can reach high concentrations in the intestinal lumen, and produces its potent amebicidal effect precisely at the site of infection, without any significant systemic absorption.

None reported

Safety for use during pregnancy and in nursing mother has not been established