Possible disulfram-like reaction may exist between omidazole and alcohol.

Concomittant oral anticoagulants may increase the risk of haemorrhage due to their diminished metabolism.

Omidazole may decrease the clearance of 5-fluorouracil.

Giardiasis

Headache, lassitude, dizziness and fatigue. Nausea, vomiting, diarrhorea, epigastric distress, anorexia, and dry mouth.

Bitter and metallic taste.

Hypersensitivity to omidazole. Special precautions: Due caution to be exercised in neurological disorders.

Blood count monitoring during treatment.

Indication-

Giardiasis

Dosage-

500mg b.i.d orally for 5 to 10 days.

Children- 25mg/kg/day single dose 5-10 days.

Pharmacology:

Antibacterial activity similar to metronidazole Pharmacokinetics: Omidazole is rapidly absorbed from the GIT. Peak plasma concentrations of about 30mcg/ml have been acheived within 2 hrs of a single dose of 1.5g.

The plasma half-life is 12- 14 hrs. The drug undergoes hepatic metabolism and is excreted in the urine.

Omidazole is advised only if the potential benefits decisively outweigh the potential risks to the fetus or neonates.